DOTA-GA(tBu)4
Based on 1 Customer Validation
DOTA-GA(tBu)4 stabilizes the attachment of radiometals to ligands. DOTA-GA(tBu)4 improves the biodistribution of radiolabeled second-generation Affibody molecules by increasing their net negative charge and reducing hepatic uptake, leading to enhanced tumor-to-blood and tumor-to-liver ratios. DOTA-GA(tBu)4 targets HER2>-expressing breast and gastrointestinal cancer.
For research use only. We do not sell to patients.
- Purity: 98.69%
- CAS No.: 306776-79-4
- Formula: C35H64N4O10
- Molecular Weight:700.90
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
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RDC Bifunctional Chelator |
DOTA-GA(tBu)4 (2 μM, 3 μM) increases total activity associated with LS174T cells over time, with internalized activity also increasing but at a slower rate[21].
DOTA-GA(tBu)4 (2 μM, 3 μM) increases total activity associated with SKOV-3 cells over time, with internalized activity also increasing but at a slower rate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 306776-79-4
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Appearance Solid
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Molecular Weight 700.90
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Formula C35H64N4O10
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Color White to off-white
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SMILES
O=C(CCC(N1CCN(CCN(CCN(CC1)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)C(OC(C)(C)C)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (142.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.4267 mL | 7.1337 mL | 14.2674 mL | 35.6684 mL |
| 5 mM | 0.2853 mL | 1.4267 mL | 2.8535 mL | 7.1337 mL | |
| 10 mM | 0.1427 mL | 0.7134 mL | 1.4267 mL | 3.5668 mL | |
| 15 mM | 0.0951 mL | 0.4756 mL | 0.9512 mL | 2.3779 mL | |
| 20 mM | 0.0713 mL | 0.3567 mL | 0.7134 mL | 1.7834 mL | |
| 25 mM | 0.0571 mL | 0.2853 mL | 0.5707 mL | 1.4267 mL | |
| 30 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1889 mL | |
| 40 mM | 0.0357 mL | 0.1783 mL | 0.3567 mL | 0.8917 mL | |
| 50 mM | 0.0285 mL | 0.1427 mL | 0.2853 mL | 0.7134 mL | |
| 60 mM | 0.0238 mL | 0.1189 mL | 0.2378 mL | 0.5945 mL | |
| 80 mM | 0.0178 mL | 0.0892 mL | 0.1783 mL | 0.4459 mL | |
| 100 mM | 0.0143 mL | 0.0713 mL | 0.1427 mL | 0.3567 mL |
DOTA-GA(tBu)4 Related Classifications
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