Mal-Deferoxamine
Based on 1 Customer Validation
Mal-Deferoxamine is a maleimide-functionalized trihydroxamate siderophore derivative that can be isolated from Streptomyces pilosus. Mal-Deferoxamine possesses highly specific Fe (III) chelating ability, and the stability of complexes formed between it and non-Fe (III) metal ions is significantly lower. Mal-Deferoxamine exhibits growth inhibitory effects against Gram-positive bacteria, but shows no obvious inhibitory activity against Gram-negative bacteria (MIC>50 μM). Mal-Deferoxamine is mainly suitable for scientific research in hematology and related fields.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1638156-31-6
- Formula: C32H53N7O11
- Molecular Weight:711.80
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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RDC Bifunctional Chelator |
Mal-Deferoxamine (0.1-20 mM Fe(III); 0.25-24 h) is highly selective for Fe(III) over Al(III) and Cr(III), adsorbs Fe(III) via a monolayer, endothermic, spontaneous process following pseudo-second-order kinetics, with a maximal adsorption capacity of 137.93 mg g-1[1].
Mal-Deferoxamine (up to 50 μM) and its Ga3+-complex do not exhibit in vitro antibacterial activity against Bacillus subtilis ATCC 6633, Staphylococcus aureus SG511, Micrococcus luteus ATCC 10240, Mycobacterium vaccae IMET 10670, or Pseudomonas aeruginosa K799/wt at concentrations up to 50 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1638156-31-6
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Appearance Solid
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Molecular Weight 711.80
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Formula C32H53N7O11
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Color White to off-white
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SMILES
O=C1C=CC(N1CCC(NCCCCCN(C(CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O)=O)O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 83.33 mg/mL (117.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4049 mL | 7.0244 mL | 14.0489 mL | 35.1222 mL |
| 5 mM | 0.2810 mL | 1.4049 mL | 2.8098 mL | 7.0244 mL | |
| 10 mM | 0.1405 mL | 0.7024 mL | 1.4049 mL | 3.5122 mL | |
| 15 mM | 0.0937 mL | 0.4683 mL | 0.9366 mL | 2.3415 mL | |
| 20 mM | 0.0702 mL | 0.3512 mL | 0.7024 mL | 1.7561 mL | |
| 25 mM | 0.0562 mL | 0.2810 mL | 0.5620 mL | 1.4049 mL | |
| 30 mM | 0.0468 mL | 0.2341 mL | 0.4683 mL | 1.1707 mL | |
| 40 mM | 0.0351 mL | 0.1756 mL | 0.3512 mL | 0.8781 mL | |
| 50 mM | 0.0281 mL | 0.1405 mL | 0.2810 mL | 0.7024 mL | |
| 60 mM | 0.0234 mL | 0.1171 mL | 0.2341 mL | 0.5854 mL | |
| 80 mM | 0.0176 mL | 0.0878 mL | 0.1756 mL | 0.4390 mL | |
| 100 mM | 0.0140 mL | 0.0702 mL | 0.1405 mL | 0.3512 mL |
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