1638156-31-6
Chemical Structure
Mal-Deferoxamine
- CAS No.: 1638156-31-6
- Formula:C32H53N7O11
- Molecular Weight:711.80
IUPAC Name: N1-(5-(3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)pentyl)-N1-hydroxy-N4-(5-(N-hydroxy-4-((5-(N-hydroxyacetamido)pentyl)amino)-4-oxobutanamido)pentyl)succinamide
InChIKey: WVJJZZJONDZKRF-UHFFFAOYSA-N
SMILES: O=C1C=CC(N1CCC(NCCCCCN(C(CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O)=O)O)=O)=O
Biological Activity: Mal-Deferoxamine is a maleimide-functionalized trihydroxamate siderophore derivative that can be isolated from Streptomyces pilosus. Mal-Deferoxamine possesses highly specific Fe (III) chelating ability, and the stability of complexes formed between it and non-Fe (III) metal ions is significantly lower. Mal-Deferoxamine exhibits growth inhibitory effects against Gram-positive bacteria, but shows no obvious inhibitory activity against Gram-negative bacteria (MIC>50 μM). Mal-Deferoxamine is mainly suitable for scientific research in hematology and related fields[1][2].
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Mal-Deferoxamine | 95.0% | Mal-Deferoxamine is a maleimide-functionalized trihydroxamate siderophore derivative that can be isolated from Streptomyces pilosus. Mal-Deferoxamine possesses highly specific Fe (III) chelating ability, and the stability of complexes formed between it and non-Fe (III) metal ions is significantly lower. Mal-Deferoxamine exhibits growth inhibitory effects against Gram-positive bacteria, but shows no obvious inhibitory activity against Gram-negative bacteria (MIC>50 μM). Mal-Deferoxamine is mainly suitable for scientific research in hematology and related fields. | ||||||||||||||||||||
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References
- [1]. Pawlaczyk M, Schroeder G. Deferoxamine-modified hybrid materials for direct chelation of Fe (III) ions from aqueous solutions and indication of the competitiveness of in vitro complexing toward a biological system[J]. ACS omega, 2021, 6(23): 15168-15181.
- [2]. Juárez-Hernández RE, et al. Syntheses of Siderophore-Drug Conjugates Using a Convergent Thiol-Maleimide System. ACS Med Chem Lett. 2012;3(10):799-803. [Content Brief]
