p-SCN-Bn-deferoxamine
Based on 1 publication(s) in Google Scholar
P-SCN-Bn-deferoxamine is a bifunctional chelating agent that can link radioactive metal nuclides (such as Zr-89) and biological targeting molecules (such as antibodies). P-SCN-Bn-deferoxamine can be used for the research of immune PET imaging.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1222468-90-7
- Formula: C33H52N8O8S2
- Molecular Weight:752.94
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) p-SCN-Bn-deferoxamine
MoreAll Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
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RDC Linker |
p-SCN-Bn-deferoxamine is conjugated to the 5B1 antibody, after which it chelates 89Zr to form [89Zr]Zr-DFO-5B1; the radiolabeled antibody then reacts with the NHS esters on the surface of gold nanoparticles via its own amino groups, ultimately generating a nanoprobe that targets pancreatic tumors expressing CA19-9[1].
p-SCN-Bn-deferoxamine is used to construct an immune PET tracer [89Zr]Zr-DFO-SC16·56 targeting DLL3, which is employed for PET/CT imaging of neuroendocrine tumors expressing DLL3[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1222468-90-7
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Appearance Solid
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Molecular Weight 752.94
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Formula C33H52N8O8S2
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Color White to off-white
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SMILES
O=C(CCC(N(CCCCCNC(CCC(N(CCCCCNC(NC1=CC=C(C=C1)N=C=S)=S)O)=O)=O)O)=O)NCCCCCN(C(C)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 70 mg/mL (92.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Sobol NB, et al. ImmunoPET Imaging of Pancreatic Tumors with 89Zr-Labeled Gold Nanoparticle-Antibody Conjugates. Mol Imaging Biol. 2021 Feb;23(1):84-94. [Content Brief]
[2]. Tendler S, et al. Imaging with [89Zr]Zr-DFO-SC16.56 anti-DLL3 antibody in patients with high-grade neuroendocrine tumours of the lung and prostate: a phase 1/2, first-in-human trial. Lancet Oncol. 2024 Aug;25(8):1015-1024. [Content Brief]
[3]. Zhang Z, et al. PVA enema ameliorates DSS-induced acute colitis in mice. BMC Gastroenterol. 2023 Oct 30;23(1):368. [Content Brief]
[4]. Zhong Y, et al. Construction methods and biomedical applications of PVA-based hydrogels. Front Chem. 2024 Feb 15;12:1376799. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3281 mL | 6.6406 mL | 13.2813 mL | 33.2032 mL |
| 5 mM | 0.2656 mL | 1.3281 mL | 2.6563 mL | 6.6406 mL | |
| 10 mM | 0.1328 mL | 0.6641 mL | 1.3281 mL | 3.3203 mL | |
| 15 mM | 0.0885 mL | 0.4427 mL | 0.8854 mL | 2.2135 mL | |
| 20 mM | 0.0664 mL | 0.3320 mL | 0.6641 mL | 1.6602 mL | |
| 25 mM | 0.0531 mL | 0.2656 mL | 0.5313 mL | 1.3281 mL | |
| 30 mM | 0.0443 mL | 0.2214 mL | 0.4427 mL | 1.1068 mL | |
| 40 mM | 0.0332 mL | 0.1660 mL | 0.3320 mL | 0.8301 mL | |
| 50 mM | 0.0266 mL | 0.1328 mL | 0.2656 mL | 0.6641 mL | |
| 60 mM | 0.0221 mL | 0.1107 mL | 0.2214 mL | 0.5534 mL | |
| 80 mM | 0.0166 mL | 0.0830 mL | 0.1660 mL | 0.4150 mL |
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