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Cat. No.: HY-158072

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DOTAM-NHS-ester

DOTAM-NHS-ester is a bifunctional chelator and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-NHS-ester combines the efficient metal chelating ability of DOTAM macrocyclic ligands with the bioconjugation function of NHS ester active groups, and can be widely used in the biomedical field for metal labeling, molecular imaging and drug delivery development.

For research use only. We do not sell to patients.

CAS No.: 2236057-47-7
Formula: C₂₀H₃₄N₈O₇
Molecular Weight:498.53

Storage:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Data Sheet (270 KB)

DOTAM-NHS-ester Chemical Structure

CAS No.: 2236057-47-7

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

RDC Bifunctional Chelator

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

In Vitro

DOTAM-NHS ester (composed of DOTAM and NHS ester) is a chelator that forms stable complexes with various metal ions and reacts with amino groups to form stable amide bonds; it is used as a biomolecule labeling reagent to introduce DOTAM into biomolecules for localization and tracking, applied to prepare metal ion-labeled probes for bioimaging, and serves as a contrast agent to improve imaging contrast and resolution by binding to specific biomolecules^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2236057-47-7
Appearance Solid
Molecular Weight 498.53
Formula C₂₀H₃₄N₈O₇
Color White to off-white
SMILES

O=C(ON1C(CCC1=O)=O)CN2CCN(CC(N)=O)CCN(CC(N)=O)CCN(CC(N)=O)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Malmberg E, et al. Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with ¹¹¹In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts[J]. European Journal of Nuclear Medicine and Molecular Imaging, 2012, 39(3): 481-492.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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