DOTAM-NHS-ester 

DOTAM-NHS-ester is a bifunctional chelator and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-NHS-ester combines the efficient metal chelating ability of DOTAM macrocyclic ligands with the bioconjugation function of NHS ester active groups, and can be widely used in the biomedical field for metal labeling, molecular imaging and drug delivery development^[1].

DOTAM-NHS ester (composed of DOTAM and NHS ester) is a chelator that forms stable complexes with various metal ions and reacts with amino groups to form stable amide bonds; it is used as a biomolecule labeling reagent to introduce DOTAM into biomolecules for localization and tracking, applied to prepare metal ion-labeled probes for bioimaging, and serves as a contrast agent to improve imaging contrast and resolution by binding to specific biomolecules^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

498.53

C₂₀H₃₄N₈O₇

2236057-47-7

Solid

White to off-white

O=C(ON1C(CCC1=O)=O)CN2CCN(CC(N)=O)CCN(CC(N)=O)CCN(CC(N)=O)CC2

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Malmberg E, et al. Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with ¹¹¹In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts[J]. European Journal of Nuclear Medicine and Molecular Imaging, 2012, 39(3): 481-492.