NH2-NODAGA hydrochloride
NH2-NODAGA hydrochloride is an amino-modified NODAGA-type bifunctional chelator, specifically designed for amidation coupling with targeting ligands via squaric acid (SA), followed by coordination with radionuclides (e.g., 68Ga, 177Lu). NH2-NODAGA hydrochloride can be coupled with diethyl squarate to form a PSMA inhibitor conjugate, which is used in prostate cancer research.
For research use only. We do not sell to patients.
- Formula: C17H32ClN5O7
- Molecular Weight:453.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
NH2-NODAGA hydrochloride reacts with diethyl squarate in 0.5M phosphate buffer to yield NODAGA.SA. NODAGA.SA can target L-lysyl urea-L-glutamate (KuE), a key structure of prostate-specific membrane antigen (PSMA). NODAGA.SA.KuE can chelate 68Ga and enable PET imaging of NMRInu/nu nude mice bearing LNCaP tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 453.92
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Formula C17H32ClN5O7
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SMILES
O=C(CN1CCN(CCN(C(CCC(NCCN)=O)C(O)=O)CC1)CC(O)=O)O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NH2-NODAGA hydrochloride Related Classifications
HY-164575B Related Classifications
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