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Cu probe

" in MedChemExpress (MCE) Product Catalog:

41

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31

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1

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1

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5

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-141511
    Coppersensor 1
    Maximum Cited Publications
    29 Publications Verification

    		 Fluorescent Dye Neurological Disease Cancer
    Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu + with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu +) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases .
    Coppersensor 1
  • HY-151708
    CalFluor 488 Azide

    		Fluorescent Dye Others
    CalFluor 488 Azide is a water-soluble fluorogenic azide probe. CalFluor 488 Azide is activated by Cu-catalyzed or metal-free click reaction. CalFluor 488 Azide is not fluorescent until it is reacted with alkynes . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    CalFluor 488 Azide
  • HY-150086
    Copper Fluor-4
    3 Publications Verification

    CF4

    		 Fluorescent Dye Others
    Copper Fluor-4 (CF4) is a Cu +-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity with a Kd value of 2.9×10 −13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission) .
    Copper Fluor-4
  • HY-W782083
    p-SCN-Bn-NOTA trihydrochloride

    		Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs) Bombesin Receptor EGFR Cancer
    p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer .
    p-SCN-Bn-NOTA trihydrochloride
  • HY-D1601
    N-Aminofluorescein
    1 Publications Verification

    		 Fluorescent Dye Others
    N-Aminofluorescein is a fluorescein hydrazide with spiro form, a highly selective and sensitive fluorescence probe for Cu 2+. N-Aminofluorescein has no selective fluorescence response to other common metal ions, can be used for direct detection of Cu 2+ in biological systems with λex/em=495/516 nm . N-Aminofluorescein can be used to measure the concentration of copper ions in cells .
    N-Aminofluorescein
  • HY-W753658
    Coppersensor-3

    		Fluorescent Dye Others
    Coppersensor-3 (CS3) is a bright small-molecule fluorescent probe for selective Cu(I) detection. Coppersensor-3 is selective and sensitive enough to image labile copper pools in living cells at endogenous, basal levels. Coppersensor-3 can be used for the cell biology of copper research .
    Coppersensor-3
  • HY-P11057
    FGGH

    		Fluorescent Dye Others
    FGGH is a water-soluble peptide-based probe. FGGH performs the sequential detection of Cu 2+ and S 2- by fluorescence and colorimetry with high sensitivity (LOD: 1.42 and 22.2 nM for Cu 2+ and S 2-, respectively) (Ex=488 nm, Em=525 nm), and images both two ions in living cells and zebrafish models with low cytotoxicity. FGGH can be used for in vivo imaging and environmental pollution monitoring research .
    FGGH
  • HY-W018008
    Ethynylferrocene

    Ferrocenylacetylene; Ferrocenylethyne

    		 Biochemical Assay Reagents Others
    Ethynylferrocene (Ferrocenylacetylene) is a click chemistry agent. Ethynylferrocene can be used for labeling of hairpin DNA probes to monitor the DNA hybridization via the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) .
    Ethynylferrocene
  • HY-D2289
    CalFluor 647 azide

    		Fluorescent Dye Others
    CalFluor 647 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 647 azide is not fluorescent until it is reacted with alkynes .
    CalFluor 647 azide
  • HY-N16571
    Marionol

    		Fluorescent Dye Endogenous Metabolite Others
    Marionol is a type of flavonol compound and belongs to the secondary metabolites of plants. Marionol exhibits significant specificity towards Cu²⁺ and possesses the characteristic of intramolecular proton transfer in excited state (ESIPT), enabling it to generate strong fluorescence upon excitation by ultraviolet light. The maximum excitation/emission wavelengths are 350 nm and 510 nm (depending on the solvent), respectively. Marionol can be used as a fluorescence probe for Cu²⁺ .
    Marionol
  • HY-147104
    Fmoc-Lys(5-FITC)-OH

    		Fluorescent Dye Others
    Fmoc-Lys(5-FITC)-OH is a marker for polypeptides or proteins. FITC is a fluorescence probe for the labeling of amines. FITC is a pH- and Cu 2+-sensitive fluorescence dye .
    Fmoc-Lys(5-FITC)-OH
  • HY-W800701
    BP Fluor 546 DBCO

    		Biochemical Assay Reagents Others
    BP Fluor 546 DBCO is an azide-reactive probe that can be used for imaging azide-tagged biomolecules via a copper-free click reaction. The DBCO moiety reacts with azides to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 546 DBCO is an ideal alternative to copper-requiring fluorescent alkynes. BP Fluor 546 is a water-soluble, pH-insensitive (from pH 4-10), orange-fluorescent dye with absorption and emission maxima at 554 and 570 nm, respectively. It can be used with the 488 nm and 532 nm laser lines. BP Fluor 546 dye conjugates to a variety of antibodies, peptides, proteins, tracers, and amplification substrates, which are often used for generating stable signals in imaging and flow cytometry.
    BP Fluor 546 DBCO
  • HY-D2288
    CalFluor 580 azide

    		Fluorescent Dye Others
    CalFluor 580 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 580 azide is not fluorescent until it is reacted with alkynes .
    CalFluor 580 azide
  • HY-W800696
    BP Fluor 430 azide

    		Fluorescent Dye Others
    BP Fluor 430 Azide is a water-soluble, green-fluorescent, azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. BP Fluor 430 is a bright, photostable, green-fluorescent probe with excitation near its absorption maximum at 432 nm and emission maximum at 539 nm. This probe is water soluble and pH-insensitive from pH 4 to pH 10. A next generation probe, BP Fluor 430 Picolyl Azide, is also available for detection of low abundance alkyne-tagged biomolecules.
    BP Fluor 430 azide
  • HY-151691
    Trisulfo-Cy3 Methyltetrazine

    		ADC Linker Others
    Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures .
    Trisulfo-Cy3 Methyltetrazine
  • HY-W800692
    BP Fluor 350 azide

    		Fluorescent Dye Others
    BP Fluor 350 Azide is a blue-fluorescent, azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. BP Fluor 350 is a water-soluble, moderately photostable, blue-fluorescent probe optimally excited by the 350 nm laser line. It is routinely used for generation of stable signal in imaging and flow cytometry. The brightness and photostability of blue dyes are best suited to direct imaging of high-abundance targets.
    BP Fluor 350 azide
  • HY-W800697
    BP Fluor 430 picolyl azide

    		Fluorescent Dye Others
    BP Fluor 430 Picolyl Azide is an advanced fluorescent probe that incorporatess a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site. The rate of the CuAAC reaction depends on the concentrations of all reagents, including copper, therefore raising the effective copper concentration at the reaction site will dramatically increase the rate of CuAAC reaction without the need to increase concentration of azide reagent or copper. In addition, the use of BP Fluor 430 Picolyl Azide instead of conventional BP Fluor 430 Azide allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling. In summary, the introduction of a picolyl moiety into an azide probe leads to a substantial increase in the sensitivity of alkyne detection. This is of special value for the detection of low abundance targets or where significant increase in signal intensity is desired.
    BP Fluor 430 picolyl azide
  • HY-D3216
    ER-Cu(II)

    		Fluorescent Dye Others
    ER-Cu (II) is an endoplasmic reticulum-selective fluorescent Cu 2+ probe. ER-Cu (II) localizes specifically to the endoplasmic reticulum of hepatocytes .
    ER-Cu(II)
  • HY-D3213
    Mem-Cu(II)

    		Fluorescent Dye Others
    Mem-Cu (II) is a cell membrane-targeted divalent copper ion (Cu 2+) probe .
    Mem-Cu(II)
  • HY-D3214
    NIR-Cu(Ⅱ)

    		Fluorescent Dye Others
    NIR-Cu (Ⅱ) is a near-infrared fluorescent Cu 2+ probe. NIR-Cu (Ⅱ) enables fluorescence imaging of Cu 2+ in living mice. NIR-Cu (Ⅱ) reduces self-absorption and exhibits minimal photobleaching, thus supporting in vivo imaging applications .
    NIR-Cu(Ⅱ)
  • HY-D3215
    Lyso-Cu(II)

    		Fluorescent Dye Neurological Disease
    Lyso-Cu (II) is a lysosome-targeted divalent copper ion probe. Lyso-Cu (II) is applicable to the research of Wilson's disease, Menkes disease and Alzheimer's disease .
    Lyso-Cu(II)
  • HY-D3205
    Bis(picolinoyl)fluorescein

    		Fluorescent Dye Others
    Bis (picolinoyl) fluorescein is a Cu 2+ esterase activity probe with both fluorogenic and chromogenic properties. Bis (picolinoyl) fluorescein enables quantitative analysis of free Cu 2+, as well as detection of esterolytic activity of Cu bound to organic ligands or biomolecules .
    Bis(picolinoyl)fluorescein
  • HY-178221
    (S)-P-SCN-BN-NOTA

    		Drug Intermediate Cancer
    (S)-P-SCN-BN-NOTA is a bifunctional chelating agent that can covalently link the radioactive nuclide ⁶⁴Cu with the ZPDGFRβ affibody, thereby constructing a molecular probe [⁶⁴Cu]Cu-NOTA-ZPDGFRβ for positron emission tomography .
    (S)-P-SCN-BN-NOTA
  • HY-D3152
    NRh-Cu

    		Fluorescent Dye Others
    NRh-Cu is a highly sensitive near-infrared fluorescence turn-on indicator and Cu 2+-selective probe (λex=680 nm, λem=740 nm). When NRh-Cu interacts with Cu 2+, it undergoes a structural transition from a non-fluorescent spirocyclic state to a fluorescent ring-opened state, which drives the enhancement of fluorescence emission. NRh-Cu can be used for Cu 2+ imaging in live cells and in vivo .
    NRh-Cu
  • HY-D3269
    Mito-Cu(II)

    		Fluorescent Dye Others
    Mito-Cu (II) is a mitochondria-targeted fluorescent probe (Ex/Em = 370/450 nM). Mito-Cu (II) specifically accumulates in mitochondria of living cells and enables real-time detection of exogenous Cu 2+ within mitochondria of living cells. Mito-Cu (II) achieves "on-off-on" fluorescence switching through sequential exposure to Cu 2+ and ethylenediaminetetraacetic acid (EDTA) (HY-Y0682). Its fluorescence is quenched after forming a 1:1 complex with Cu 2+, and the fluorescence recovers when Cu 2+ is chelated by EDTA .
    Mito-Cu(II)
  • HY-D3200
    Dns–LLC

    		Fluorescent Dye Cuproptosis Others
    Dns-LLC is a cell-permeable Cu +-selective fluorescent probe that forms a 1:1 complex with Cu +. The thiol group of Dns-LLC plays a key binding role, while the sulfonamide and amide groups jointly contribute to the stabilization of the complex. Upon binding to Cu + in aqueous buffer solutions, Dns-LLC generates a turn-on fluorescence response, which can be used for the detection of Cu + in the Golgi apparatus .
    Dns–LLC
  • HY-D3241
    CD649.2

    		Fluorescent Dye Others
    CD649.2 is a red-emitting copper-targeted acylimidazole-reactive Fluorescent probe and a highly specific Cu 2+ detection reagent. CD649.2 enables visualization of labile Cu 2+ pools and their dynamic changes in living cells .
    CD649.2
  • HY-D3284
    CSF1

    		Fluorescent Dye Others
    CSF1 is a silicon-rhodamine-based, fluorescence-activatable probe with selectivity for Cu +. CSF1 colocalizes with the endoplasmic reticulum in live cells .
    CSF1
  • HY-D3267
    ACu1

    		Fluorescent Dye Others
    ACu1 is a copper (I)-selective two-photon fluorescent probe that enables the visual imaging of Cu + distribution in living cells and tissues .
    ACu1
  • HY-D2969
    CYDA

    		Fluorescent Dye Metabolic Disease
    CYDA is a colorimetric probe based on cyanine dyes, which enables highly sensitive and selective detection of Cu²⁺. CYDA can be used for urine copper detection in Wilson's disease .
    CYDA
  • HY-D3255
    CTAP-1

    		Fluorescent Dye Others
    CTAP-1 is a monovalent copper ion probe. CTAP-1 binds to monovalent copper Cu (I) to inhibit photoinduced electron transfer, thereby enhancing fluorescence emission. CTAP-1 produces copper-dependent perinuclear staining that colocalizes with mitochondria and the Golgi apparatus. CTAP-1 can be used for imaging Cu (I) pools, excitation/emission Wavelength: 365/480 nm .
    CTAP-1
  • HY-D3233
    Ctrl-BDPS1

    		Fluorescent Dye Others
    Ctrl-BDPS1 is a BODIPY-based control probe that shows no response to copper ions (exhibiting two emission peaks at 575 nm and 708 nm; the maximum excitation wavelength is at 627 nm). Ctrl-BDPS1 has no fluorescent response to Cu + .
    Ctrl-BDPS1
  • HY-D3207
    DHUCu-1

    		Fluorescent Dye Neurological Disease
    DHUCu-1 is a lysosome-targeted NIR divalent copper ion probe with high water solubility. DHUCu-1 serves as a tool for investigating the physiological functions of Cu 2+ and related diseases, such as Menke syndrome, Wilson's disease, and Alzheimer's disease .
    DHUCu-1
  • HY-DY1087
    Coppersensor 1 (solution)

    		Fluorescent Dye Cancer
    Coppersensor 1 (solution) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu + with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu +) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases .
    Solvent and concentration: DMSO: 2 mM
    Coppersensor 1 (solution)
  • HY-W800691
    BP Fluor 350 picolyl azide

    		Fluorescent Dye Others
    BP Fluor 350 Picolyl Azide is a blue-fluorescent azide-activated probe that reacts with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free click chemistry reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures.
    BP Fluor 350 picolyl azide
  • HY-203233
    Rhodamine-DHPE

    		Fluorescent Dye Others
    Rhodamine-DHPE is a fluorescently labeled phosphatidylethanolamine lipid that labels phospholipid bilayers. Rhodamine-DHPE serves as a fluorescence quenching substrate and membrane stain. The fluorescence lifetime of Rhodamine-DHPE decreases significantly in the presence of Cu 2+-PS complexes. Rhodamine-DHPE effectively stains the membranes of human red blood cells and mouse fibroblasts, and supports lifetime-resolved imaging via pump-probe fluorescence microscopy .
    Rhodamine-DHPE
  • HY-D3153
    PbQ

    		Apoptosis Caspase Microtubule/Tubulin Inflammation/Immunology
    PbQ is a tubulin inhibitor (with an IC50 of 5 μM against goat tubulin) and a fluorescent probe for cuprous ions Cu (I). PbQ can penetrate the membrane of peripheral blood mononuclear cells, form a stable 1:1 complex with Cu + ions, and exhibits low toxicity and good biocompatibility toward macrophage cell lines. In addition, PbQ promotes tubulin degradation and disrupts the microtubule network in lung epithelial cells without affecting actin. PbQ also possesses genotoxicity by forming DNA base adducts, and it can activate caspase-3 and apoptosis-related genes, induce loss of mitochondrial membrane potential, and trigger cell apoptosis. PbQ can be used in studies related to chronic obstructive pulmonary disease .
    PbQ
  • HY-W800693
    BP Fluor 405 picolyl azide

    		Fluorescent Dye Others
    BP Fluor 405 Picolyl Azide is an advanced fluorescent probe that incorporatess a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site. The rate of the CuAAC reaction depends on the concentrations of all reagents, including copper, therefore raising the effective copper concentration at the reaction site dramatically increases the rate of CuAAC reaction without increasing the concentrations of azide reagent or copper. In addition, the use of picolyl azide instead of conventional azides allows for at least a tenfold reduction in the concentration of the copper catalyst without sacrificing the efficiency of labeling. In summary, the introduction of a picolyl moiety into an azide probe leads to a substantial increase in the sensitivity of alkyne detection. This is of special value for the detection of low abundance targets or where significant increase in signal intensity is desired.
    BP Fluor 405 picolyl azide
  • HY-DY1104
    Copper Fluor-4 (solution)

    CF4 (solution)

    		 Fluorescent Dye Others
    Copper Fluor-4 (solution) (CF4 (solution)) is a Cu +-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 solution has high copper selectivity with a Kd value of 2.9×10 ?13 M, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 solution is stable in a physiologically relevant pH regime between 6 and 8 (wavelengths of 415 nm for excitation and 660 nm for emission) .
    Solvent and concentration: DMSO: 5 mM
    Copper Fluor-4 (solution)
  • HY-W800699
    BP Fluor 430 DBCO

    		Fluorescent Dye Others
    BP Fluor 430 DBCO reacts with azides via a copper-free click chemistry reaction to form a stable triazole and does not require a Cu-catalyst or elevated temperatures. In applications where the presence of copper is a concern, BP Fluor 430 DBCO is an ideal alternative to copper requiring fluorescent alkynes. BP Fluor 430 is a bright, photostable, green-fluorescent probe optimally excited near its absorption maximum at 432 nm. Its emission peak at 539 nm is pH independent over a wide pH range. BP Fluor DBCO reagent is not suitable for staining intracellular components of fixed and permeabilized cells due to high backgrounds.
    BP Fluor 430 DBCO
  • HY-W783351
    CS790AM

    Coppersensor 790 acetoxymethyl ester

    		 Fluorescent Dye Metabolic Disease
    CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu +-targeted near-infrared fluorescent probe (λabs=760 nm, λem=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible "turn-on" detection of labile Cu + pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilson's disease models (Atp7b -/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilson's disease and related copper metabolic disorders .
    CS790AM

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