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Cat. No.: HY-D3207

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DHUCu-1

DHUCu-1 is a lysosome-targeted NIR divalent copper ion probe with high water solubility. DHUCu-1 serves as a tool for investigating the physiological functions of Cu²⁺ and related diseases, such as Menke syndrome, Wilson's disease, and Alzheimer's disease.

For research use only. We do not sell to patients.

CAS No.: 3037311-41-1
Formula: C₁₇H₂₁N₅OS
Molecular Weight:343.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DHUCu-1 Chemical Structure

CAS No.: 3037311-41-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

DHUCu-1 (5 μM) exhibits concentration-dependent fluorescence and absorbance changes with Cu²⁺ (0-20 μM) in PBS solution containing 1% alcohol cosolvent, enabling visual and spectroscopic detection of Cu²⁺^[1].
DHUCu-1 (5 μM) enables highly sensitive detection of Cu²⁺ in aqueous solution, with a limit of detection of 19.1 nM, and shows a linear fluorescence response to Cu²⁺ in the concentration range of 0 to 3.0 μM^[1].
DHUCu-1 (50 μM; 24 h) exhibits low toxicity and good biocompatibility toward HeLa cells, with an observed cell viability of over 80%^[1].
DHUCu-1 (10 μM; 1 h) acts as an activatable fluorescent probe for exogenous Cu²⁺ (20-50 μM; 1 h) in HeLa cells, generating a detectable near-infrared fluorescent signal^[1].
DHUCu-1 (10 μM; 1 h) accumulates in the lysosomes of HeLa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa cells
Concentration:

50 μM
Incubation Time:

24 h
Result:

Maintained HeLa cell survival rate above 80% after incubation.

Chemical Information

CAS No. 3037311-41-1
Molecular Weight 343.45
Formula C₁₇H₂₁N₅OS
SMILES

CN(C1=CC=C2C(SC3=C(N2C(NN)=O)C=CC(N(C)C)=C3)=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yin Chen, et al. A lysosome-targeted near-infrared fluorescent probe for cell imaging
of Cu2+. Dyes and Pigments 204 (2022) 110472.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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