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Cat. No.: HY-D3200

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Dns–LLC

Dns-LLC is a cell-permeable Cu⁺-selective fluorescent probe that forms a 1:1 complex with Cu⁺. The thiol group of Dns-LLC plays a key binding role, while the sulfonamide and amide groups jointly contribute to the stabilization of the complex. Upon binding to Cu⁺ in aqueous buffer solutions, Dns-LLC generates a turn-on fluorescence response, which can be used for the detection of Cu⁺ in the Golgi apparatus.

For research use only. We do not sell to patients.

CAS No.: 3112200-59-3
Formula: C₂₇H₄₁N₅O₅S₂
Molecular Weight:579.77

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Please store the product under the recommended conditions in the Certificate of Analysis.

Dns–LLC Chemical Structure

CAS No.: 3112200-59-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

In Vitro

Dns-LLC (10 μM) forms a 1:1 complex with Cu⁺ in buffered aqueous solution at physiological pH, exhibits approximately 12-fold fluorescence turn-on enhancement towards Cu⁺, and has a femtomolar-level binding affinity (K_d=12 fM)^[1].
Dns-LLC (20 μM; 30 min) penetrates live human colorectal RKO cells, selectively detects intracellular Cu⁺ via a turn-on fluorescence response, localizes to the Golgi apparatus to detect Cu⁺ in this organelle, and exhibits no obvious cytotoxicity against RKO cells^[1].
Dns-LLC holds potential for the study of cuproptosis.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3112200-59-3
Molecular Weight 579.77
Formula C₂₇H₄₁N₅O₅S₂
SMILES

CN(C)C(C1=CC=C2)=CC=CC1=C2S(=O)(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CS)C(N)=O)=O)=O)CC(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jung KH, et al. Development of new peptide-based receptor of fluorescent probe with femtomolar affinity for Cu(+) and detection of Cu(+) in Golgi apparatus. Biosens Bioelectron. 2016;85:437-444. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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