CTAP-1 

CTAP-1 is a monovalent copper ion probe. CTAP-1 binds to monovalent copper Cu (I) to inhibit photoinduced electron transfer, thereby enhancing fluorescence emission. CTAP-1 produces copper-dependent perinuclear staining that colocalizes with mitochondria and the Golgi apparatus. CTAP-1 can be used for imaging Cu (I) pools, excitation/emission Wavelength: 365/480 nm^[1].

CTAP-1 (10 μM; 50 min incubation) labels a perinuclear, copper-dependent labile copper pool in NIH 3T3 fibroblast cells, with fluorescence intensity increasing ~2- to 3-fold in copper-supplemented medium, and staining colocalizing with mitochondria and the Golgi apparatus^[1].
CTAP-1 (2 μM) fluorescence in copper-loaded NIH 3T3 fibroblast cells is reduced by ~50% upon treatment with the exogenous Cu⁺ chelator DTO, confirming the signal is copper-dependent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

623.92

C₃₂H₃₇N₃O₂S₄

866534-64-7

[H][C@]1(CC(C2=CC=CC=C2)=NN1C3=CC=C(C(O)=O)C=C3)C(C=C4)=CC=C4N5CCSCCSCCSCCSCC5

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• [1]. Yang L, et al. Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy. Proc Natl Acad Sci U S A. 2005;102(32):11179-11184.  [Content Brief]