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Results for "

MSI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) ATM/ATR (1) Bacterial (5) Dengue Virus (1) DNA/RNA Synthesis (17) FAK (1) HBV (1) PAK (1) Phosphatase (4) Reference Standards (1) Small Interfering RNA (siRNA) (7) α-synuclein (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (1) Endocrinology (2) Infection (5) Metabolic Disease (3) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (2) siRNAs (7)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-158116

VVD-214 RO7589831; VVD-133214	DNA/RNA Synthesis	Cancer
VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC₅₀ of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers .

HY-16468

Squalamine 1 Publications Verification MSI-1256; ENT-01 free acid	Bacterial HBV FAK Dengue Virus	Infection Neurological Disease Cancer
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson ^,s disease mouse models .

HY-108466

Ro 08-2750 4 Publications Verification	Apoptosis	Neurological Disease Cancer
Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC₅₀ of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75 ^NTR selectively over TRKA . Ro 08-2750 is a selective _{MSI RNA-binding} activity inhibitor, with an IC₅₀ of 2.7 μM .

HY-169422

GSK4418959 IDE275	DNA/RNA Synthesis	Cancer
GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC) .

HY-12219A

MSI-1436 lactate Maximum Cited Publications 8 Publications Verification Trodusquemine lactate; Aminosterol-1436 lactate	Phosphatase	Endocrinology
MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 1 μM, 200-fold preference over TCPTP (IC₅₀ of 224 μM).

HY-105088

Pexiganan MSI 78 free base	Bacterial	Infection
Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .

HY-121515

DPM-1001	Phosphatase	Metabolic Disease
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property .

HY-12219

MSI-1436 Trodusquemine; Aminosterol-1436	Phosphatase	Endocrinology
MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of appr 1 μM, 200-fold preference over TCPTP (IC₅₀, 224 μM).

HY-162471

GSK_WRN3	DNA/RNA Synthesis ATM/ATR	Cancer
GSK_WRN3 is selective WRN helicase inhibitor (pIC₅₀ = 8.6). SK_WRN3 can selectively inhibit the growth of microsatellite unstable (MSI) cancer cells, induce DNA damage, and cause cell cycle arrest. GSK_WRN3 has anti-tumor activity .

HY-163942

GSK_WRN4	DNA/RNA Synthesis	Cancer
GSK_WRN4 is an orally active WRN helicase inhibitor (pIC₅₀=7.6). GSK_WRN4 induces DNA damage markers (p21, p-γH2AX, p-KAP1). GSK_WRN4 selectively inhibits microsatellite-unstable tumor growth in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and regions of DNA damage .

HY-121515A

DPM-1001 trihydrochloride	Phosphatase	Metabolic Disease
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property .

HY-119734

Gossypolone	DNA/RNA Synthesis	Cancer
Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a K_i of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer .

HY-169422A

GSK4418959 (enantiomer) IDE275 (enantiomer)	DNA/RNA Synthesis	Cancer
GSK4418959 enantiomer is an enantiomer of GSK4418959 (HY-169422). GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer .

HY-16467

Squalamine lactate 1 Publications Verification MSI-1256F	Bacterial	Infection Cardiovascular Disease Cancer
Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

HY-156581

WRN inhibitor 5	DNA/RNA Synthesis	Cancer
WRN inhibitor 5, a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 5 can be used for the research of cancer, including cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR) .

HY-105088A

Pexiganan acetate MSI 78	Bacterial	Infection
Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection .

HY-16468A

Squalamine phosphate ENT 01; MSI-1256 phosphate	α-synuclein	Neurological Disease
Squalamine phosphate (Compound ENT-01) is an orally active neuroprotective agent. Squalamine phosphate can displace α-Syn that is bound electrostatically to nerve cell membranes and prevent aggregation of α-Syn. Squalamine phosphate can be used for the research of neurological disease, such as Parkinson’s disease .

HY-178991

WRN-IN-21	DNA/RNA Synthesis	Cancer
WRN-IN-21 (Compound 11b) is a WRN helicase inhibitor with pIC₅₀ values for WRN and BLM helicases of 3.6 and 5.4 respectively. WRN-IN-21 can be used for the study of MSI-related cancers .

HY-161386

WRN inhibitor 7	DNA/RNA Synthesis	Cancer
WRN inhibitor 7 (Compound h6) is a WRN inhibitor. WRN inhibitor 7 effectively inhibits WRN's helicase and ATPase activity (IC₅₀: 9.8 μM and 15.8 μM respectively). WRN inhibitor 7 can be used for research of microsatellite instable (MSI) cancers .

HY-174217

WRN-IN-19	DNA/RNA Synthesis	Cancer
WRN-IN-19 (Compound (S)-27) is a covalent WRN helicase inhibitor, with pIC50 (0 h/4 h) = 5.4/7.5 in the DNA-unwinding 5 endpoint assays. WRN-IN-19 shows synthetic lethality in MSI-H (high microsatellite instability) cancer cells .

HY-168934

KWR137	DNA/RNA Synthesis	Cancer
KWR137 is a WRN degrader, with an IC₅₀ of 8 nM. KWR137 exhibits good anti-proliferative activity against MSI-H cells, with a GI₅₀ of 509 nM in SW48 cells and a GI₅₀ of 824 μM in HCT116 cells. It also demonstrates anti-tumor growth effects in xenograft mouse models. KWR137 can be used for cancer research .

HY-12219B

MSI-1701	Others	Metabolic Disease
MSI-1701 is an analogue of MSI-1436 which can control weight gain and blood glucose level extracted from patent US 7410959 B1.

HY-178474

WRN-IN-20	DNA/RNA Synthesis Apoptosis	Cancer
WRN inhibitor 20 (Compound 14c) is a WRN degradation agent. WRN inhibitor 20 exhibits strong degradation activity in various cells, such as HCT-116 (DC₅₀ = 1.7 µM), SW-48 (DC₅₀ = 3.0 µM), and SW-480 (DC₅₀ = 5.9 µM) cells. WRN inhibitor 20 exhibits potent anti proliferative, pro apoptotic, migration inhibiting, and DNA damage inducing effects in MSI-H cells. WRN inhibitor 20 can be used for research on cancer .

HY-RS08714

MSI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MSI1 Human Pre-designed siRNA Set A contains three designed siRNAs for MSI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MSI1 Human Pre-designed siRNA Set A MSI1 Human Pre-designed siRNA Set A

HY-RS08715

MSI2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MSI2 Human Pre-designed siRNA Set A contains three designed siRNAs for MSI2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MSI2 Human Pre-designed siRNA Set A MSI2 Human Pre-designed siRNA Set A

HY-RS21378

Msi2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Msi2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Msi2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Msi2 Mouse Pre-designed siRNA Set A Msi2 Mouse Pre-designed siRNA Set A

HY-RS22242

Msi1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Msi1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Msi1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Msi1 Mouse Pre-designed siRNA Set A Msi1 Mouse Pre-designed siRNA Set A

HY-RS27897

Msi2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Msi2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Msi2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Msi2 Rat Pre-designed siRNA Set A Msi2 Rat Pre-designed siRNA Set A

HY-163941

GSK_WRN2	DNA/RNA Synthesis	Cancer
GSK_WRN2 is a potent and selective covalent WRN helicase inhibitor that suppresses replication stress caused by DNA (TA)_n dinucleotide repeat expansions. GSK_WRN2 can be used to study microsatellite instability (MSI) cancers .

HY-RS18892

Ebp Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ebp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ebp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ebp Mouse Pre-designed siRNA Set A Ebp Mouse Pre-designed siRNA Set A

HY-176912

WRN-IN-22	DNA/RNA Synthesis	Cancer
WRN-IN-22 (compound A01) is a potent Werner syndrome RecQ helicase (WRN) inhibitor (IC₅₀ < 100 nM). WRN-IN-22 can be used for microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) cancer research, such as colorectal, gastric, prostate and endometrial cancer .

HY-RS28764

Msi1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Msi1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Msi1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Msi1 Rat Pre-designed siRNA Set A Msi1 Rat Pre-designed siRNA Set A

HY-108466R

Ro 08-2750 (Standard)	Reference Standards Apoptosis	Neurological Disease Cancer
Ro 08-2750 (Standard) is the analytical standard of Ro 08-2750 (HY-108466). This product is intended for research and analytical applications. Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC₅₀ of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA . Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC₅₀ of 2.7 μM .

HY-179326

WRN-IN-23	DNA/RNA Synthesis	Cancer
WRN-IN-23 is a Werner Syndrome helicase enzyme (WRN) inhibitor. WRN-IN-23 inhibits the ATP-dependent helicase domain activity of WRN. WRN-IN-23 can be used for the research of cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR) .

HY-105088C

Pexiganan TFA MSI 78 TFA	Bacterial	Infection
Pexiganan TFA is an antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .

HY-183610

WRN-IN-26	DNA/RNA Synthesis PAK	Cancer
WRN-IN-26 is an orally active Werner syndrome helicase (WRN) inhibitor with a human K_i value of 58.7 μM and an IC₅₀ value of 0.026 μM. WRN-IN-26 selectively targets the cysteine residues of WRN. WRN-IN-26 induces the expression of p21 protein in MSI-H tumor cells. WRN-IN-26 inhibits the growth of MSI-H tumor cells and exhibits potent in vivo efficacy in MSI-H xenograft tumor models. WRN-IN-26 can be used for the research of microsatellite instability-high (MSI-H) cancers .

HY-179322

DHX9-IN-21	DNA/RNA Synthesis	Cancer
DHX9-IN-21 (Compound 636) is a DHX9 inhibitor with an IC₅₀ of 12.2 nM; its EC₅₀ at the cellular level is 0.3 μM. DHX9-IN-21 exhibits antiproliferative activity against LS411N (CRC-MSI-H), with an IC₅₀ value of 1.21 μM. DHX9-IN-21 can be used for the research of microsatellite unstable colorectal cancer .

Cat. No.	Product Name	Target	Research Area

HY-105088

Pexiganan MSI 78 free base	Bacterial	Infection
Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .

HY-105088A

Pexiganan acetate MSI 78	Bacterial	Infection
Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection .

HY-105088C

Pexiganan TFA MSI 78 TFA	Bacterial	Infection
Pexiganan TFA is an antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .

Squalamine 1 Publications Verification MSI-1256; ENT-01 free acid	Infection Triterpenes Classification of Application Fields Animals Terpenoids Marine natural products Other marine organisms Disease Research Fields Cancer	Bacterial HBV FAK Dengue Virus
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson ^,s disease mouse models .

Pexiganan MSI 78 free base	Infection Structural Classification Natural Products Classification of Application Fields Animals Disease Research Fields Source Classification	Bacterial
Pexiganan (MSI 78) is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan TFA can be used for the research of bacterial infection .

Squalamine lactate 1 Publications Verification MSI-1256F	Cardiovascular Disease Infection Structural Classification Classification of Application Fields Animals Marine natural products Other marine organisms Disease Research Fields Steroids	Bacterial
Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

Pexiganan acetate MSI 78	Structural Classification Natural Products Animals Source Classification	Bacterial
Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703385

	MSI2 Protein, Human (His, Strep) RNA-binding protein Musashi homolog 2; MSI2; Homo sapiens; Human; Musashi-2; RNA-binding	Human	E. coli
	MSI2 Protein, Human (His, Strep) is the recombinant human-derived MSI2, expressed by E. coli , with Strep, His labeled tag. ,

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Host:	Mouse (3) Rabbit (4)
Reactivity:	Human (7) Rat (3) Mouse (3)
Application:	IHC-P (6) ICC/IF (4) IF-Tissue (2) IP (2) IHC-F (2) WB (7) FC (4) ELISA (2)
Isotype:	IgG (4) IgG1 (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (5) Monoclonal Antibody (1) Recombinant (4)
Modification:	Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85563

	*Musashi 1/Msi1 Antibody (YA5255)* MSI1; Musashi-1; MSI 1; MSI1; MSI1H_HUMAN; Musashi homolog 1; Musashi-1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1.	WB	Human, Mouse, Rat
	Musashi 1/Msi1 Antibody (YA5255) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Musashi 1/Msi1.

HY-P84725

	Musashi 2 Antibody (YA4422) MSI2H; MGC3245; FLJ36569; MSI2	WB, IHC-P, ELISA	Human
	Musashi 2 Antibody (YA4422) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Musashi 2.

HY-P84725A

	Musashi 2 Antibody (YA4422)(PBS only) MSI2H; MGC3245; FLJ36569; MSI2	WB, IHC-P, ELISA	Human
	Musashi 2 Antibody (YA4422) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Musashi 2.

HY-P83070

	*Musashi 1/Msi1 Antibody (YA2815)* RNA-binding protein Musashi homolog 1; Musashi-1; MSI1	WB, IHC-P, ICC/IF, IP, FC	Human
	Musashi 1/Msi1 Antibody (YA2815) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Musashi 1/Msi1.

HY-P85283

	*Musashi 1/Msi1 Antibody (YA4975)* MSI1; RNA-binding protein Musashi homolog 1; Musashi-1	WB, IHC-P, IHC-F, IF-Tissue, IP, FC, ICC/IF	Human
	Musashi 1/Msi1 Antibody (YA4975) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Musashi 1/Msi1.

HY-P83300

	Musashi 2 Antibody (YA3045) MSI2; RNA-binding protein Musashi homolog 2; Musashi-2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Musashi 2 Antibody (YA3045) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Musashi 2.

HY-P85284

	Musashi 2 Antibody (YA4976) MSI2; RNA-binding protein Musashi homolog 2; Musashi-2	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, FC	Human, Mouse, Rat
	Musashi 2 Antibody (YA4976) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Musashi 2.

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