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Cat. No.: HY-179322

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DHX9-IN-21

DHX9-IN-21 is a DHX9 inhibitor with an IC₅₀ of 12.2 nM; its EC₅₀ at the cellular level is 0.3 μM. DHX9-IN-21 can be used for the research of microsatellite unstable colorectal cancer.

For research use only. We do not sell to patients.

CAS No.: 2973401-72-6
Formula: C₂₀H₂₀ClN₅O₄S₂
Molecular Weight:493.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DHX9-IN-21 Chemical Structure

CAS No.: 2973401-72-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

DHX9-IN-21 (Example 636) exhibits anti-proliferative activity against LS411N (CRC-MSI-H) with an IC₅₀ value of 1.21 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2973401-72-6
Molecular Weight 493.99
Formula C₂₀H₂₀ClN₅O₄S₂
SMILES

O=C(C1=CC(C2=NC=C(C=N2)OC3CNC3)=C(C)S1)NC4=CC(Cl)=CC(NS(=O)(C)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matthew H. Daniels, et al. Inhibitors of rna helicase dhx9 and uses thereof. WO2023154519A1.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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