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Ro 08-2750 

Cat. No.: HY-108466
Handling Instructions

Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA.

For research use only. We do not sell to patients.

Ro 08-2750 Chemical Structure

Ro 08-2750 Chemical Structure

CAS No. : 37854-59-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 461 In-stock
Estimated Time of Arrival: December 31
1 mg USD 155 In-stock
Estimated Time of Arrival: December 31
5 mg USD 465 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA[1].

IC50 & Target

IC50: ~ 1 µM (NGF)[1]

In Vitro

Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore[2].
Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death[2].

Molecular Weight

270.24

Formula

C₁₃H₁₀N₄O₃

CAS No.

37854-59-4

SMILES

O=CC1=C(C)C=C2N=C3C(NC(N=C3N(C)C2=C1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Ro 08-2750OthersNGFp75(NTR)TRKAInhibitorinhibitorinhibit

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Ro 08-2750
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