1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
    Apoptosis
  2. Trk Receptor
    Apoptosis
  3. GW 441756

GW 441756 

Cat. No.: HY-18314 Purity: 99.32%
Handling Instructions

GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2.

For research use only. We do not sell to patients.

GW 441756 Chemical Structure

GW 441756 Chemical Structure

CAS No. : 504433-23-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 504 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2. IC50 Value: 2 nM [1] Target: TrkA in vitro: GW441756 specifically blocked TrkA-induced cell death in a dose-dependent manner, but there was no effect in uninduced cells. TrkA ability to induce γH2AX production was significantly downregulated by both K-252a and GW441756 in the absence of DNA damage inducer. In addition, it was also suppressed by K-252a during DNA damage by doxorubicin treatment, but not by GW441756 [2].

Molecular Weight

275.30

Formula

C₁₇H₁₃N₃O

CAS No.

504433-23-2

SMILES

O=C1/C(C2=NC=CC=C2N1)=C\C3=CN(C)C4=C3C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 17.5 mg/mL (63.57 mM; Need ultrasonic and warming)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6324 mL 18.1620 mL 36.3240 mL
5 mM 0.7265 mL 3.6324 mL 7.2648 mL
10 mM 0.3632 mL 1.8162 mL 3.6324 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.32%

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Keywords:

GW 441756GW441756GW-441756Trk ReceptorApoptosisTropomyosin related kinase receptor Inhibitorinhibitorinhibit

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Product name:
GW 441756
Cat. No.:
HY-18314
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