Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles

  • Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7. doi: 10.1016/j.bmcl.2003.12.002.
Edgar R Wood  1 ,  Lee Kuyper ,  Kimberly G Petrov ,  Robert N Hunter 3rd ,  Philip A Harris ,  Karen Lackey
Affiliations
  • 1. GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.
PMID: 15013000 DOI: 10.1016/j.bmcl.2003.12.002
Abstract

The discovery, synthesis, potential binding mode, and in vitro kinase profile of 3-(3-bromo-4-hydroxy-5-(2'-methoxyphenyl)-benzylidene)-5-bromo-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one, 3-[(1-methyl-1H-indol-3-yl)methylene]-1,3-dihydro-2H-pyrrolo[3,2-b]-pyridin-2-one as potent TrkA inhibitors are discussed.

Products