Search Result

Results for "

NEP inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neprilysin (48) Aminopeptidase (4) Androgen Receptor (2) Angiotensin Receptor (3) Angiotensin-converting Enzyme (ACE) (15) Apoptosis (3) Drug Derivative (1) Drug Metabolite (2) Endogenous Metabolite (3) Endothelin-Converting Enzyme (ECE) (1) Enteropeptidase (2) Epigenetic Reader Domain (1) ERK (2) GCGR (2) Isotope-Labeled Compounds (8) MMP (2) mTOR (2) Opioid Receptor (2) Prolyl Endopeptidase (PREP) (2) PROTACs (1) Reference Standards (5)
By Research Areas:	Cancer (4) Cardiovascular Disease (40) Endocrinology (2) Infection (5) Inflammation/Immunology (7) Metabolic Disease (10) Neurological Disease (15)

By Targets:

Neprilysin (48)

Aminopeptidase (4)

Androgen Receptor (2)

Angiotensin Receptor (3)

Angiotensin-converting Enzyme (ACE) (15)

Apoptosis (3)

Drug Derivative (1)

Drug Metabolite (2)

Endogenous Metabolite (3)

Endothelin-Converting Enzyme (ECE) (1)

Enteropeptidase (2)

Epigenetic Reader Domain (1)

ERK (2)

GCGR (2)

Isotope-Labeled Compounds (8)

MMP (2)

mTOR (2)

Opioid Receptor (2)

Prolyl Endopeptidase (PREP) (2)

PROTACs (1)

Reference Standards (5)

By Research Areas:

Cancer (4)

Cardiovascular Disease (40)

Endocrinology (2)

Infection (5)

Inflammation/Immunology (7)

Metabolic Disease (10)

Neurological Disease (15)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Neprilysin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W013375

Thiorphan 3 Publications Verification	Neprilysin	Neurological Disease
Thiorphan is a selective neprilysin (NEP) inhibitor with an IC₅₀ of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .

HY-15407

Sacubitril 3 Publications Verification AHU-377	Neprilysin	Infection Cardiovascular Disease
Sacubitril (AHU-377) is a potent and orally active *NEP* (neprilysin) inhibitor with an IC₅₀ of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19 .

HY-17620

Sacubitrilat Maximum Cited Publications 6 Publications Verification Desethyl Sacubitril; LBQ-657	Neprilysin	Neurological Disease
Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.

HY-15407B

Sacubitril sodium 3 Publications Verification AHU-377 sodium	Neprilysin	Infection Cardiovascular Disease
Sacubitril sodium is a potent and orally active *NEP* (neprilysin) inhibitor, with an IC₅₀ of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .

HY-17399

Racecadotril 3 Publications Verification Acetorphan	Neprilysin	Metabolic Disease
Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with K_is of 4500 and 6.1 nM, , respectively. Antidiarrheal agent .

HY-18208

Omapatrilat 2 Publications Verification BMS-186716	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Omapatrilat is a dual inhibitor of the metalloproteases ACE and *NEP* with K_i values of 0.64 and 0.45 nM, respectively.

HY-N2021A

Phosphoramidon disodium	MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
Phosphoramidon disodium, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC₅₀ of 0.4 μg/mL. Phosphoramidon disodium also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC₅₀ values of 3.5, 0.034, and 78 μM, respectively .

HY-15407A

Sacubitril hemicalcium salt 3 Publications Verification AHU-377 hemicalcium salt	Neprilysin	Cardiovascular Disease
Sacubitril hemicalcium salt (AHU-377 hemicalcium salt) is a potent *NEP* inhibitor with an IC₅₀ of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696.

HY-15407S

Sacubitril-d4 AHU-377-d₄	Neprilysin	Cardiovascular Disease
Sacubitril-d₄ is the deuterium labeled Sacubitril. Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril (AHU-377) is a component of the heart failure medicine LCZ696.

HY-19649

Candoxatril UK 79300	Neprilysin	Metabolic Disease
Candoxatril is a neutral endopeptidase (NEP) inhibitor.

HY-17620S

Sacubitrilat-d4 Desethyl Sacubitril-d₄; LBQ-657-d₄	Isotope-Labeled Compounds Neprilysin	Neurological Disease
Sacubitrilat-d₄ is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor .

HY-174996

NEP162	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
NEP162 is a BRD4 PROTAC degrader with DC₅₀s of 1.2 and 1.6 μM in SW480 and U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibits tumor growth and induces apoptosis. NEP162 can be used for the study of osteosarcoma, colorectal cancer and non-small cell lung cancer, etc. (Pink: BRD4 ligand : (HY-78695), Blue: E3 ligase Ligand (HY-D2259), BLACK: Linker, E3 ligase ligand-linker conjugate (HY-174997)) .

HY-P3101

GLP-1(28-36)amide	GCGR	Cardiovascular Disease Metabolic Disease
GLP-1(28-36)amide, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide has anti-diabetic and cardioprotection effects .

HY-123348

Sampatrilat UK-81252	Angiotensin-converting Enzyme (ACE) Neprilysin	Cardiovascular Disease Inflammation/Immunology
Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (K_i=13.8 nM) 12.4-fold more potent than that for the N-domain (K_i=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation .

HY-N2021

Phosphoramidon	MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology Cancer
Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC₅₀ of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC₅₀ values of 3.5, 0.034, and 78 μM, respectively .

HY-W013375S

Thiorphan-d7	Neprilysin	Neurological Disease
Thiorphan-d₇ is the deuterium labeled Thiorphan . Thiorphan is a selective NEP (neprilysin) inhibitor with an IC₅₀ of 6.9 nM .

HY-U00171

SQ28603 SQ28,603; Squibb 28603	Neprilysin	Metabolic Disease
SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).

HY-78841

(2S,4S)-Sacubitril	Drug Metabolite	Cardiovascular Disease
(2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure .

HY-U00294

NEP-In-1	Neprilysin	Neurological Disease
NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC₅₀ of 2 nM for dNEP.

HY-P5754

TAT-NEP1-40	Apoptosis	Neurological Disease
TAT-NEP1-40 is a BBB-penatrable peptide. TAT-NEP1-40 protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .

HY-17620R

Sacubitrilat (Standard) Desethyl Sacubitril (Standard); LBQ-657 (Standard)	Reference Standards Neprilysin	Neurological Disease
Sacubitrilat (Standard) is the analytical standard of Sacubitrilat. This product is intended for research and analytical applications. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.

HY-15407BR

Sacubitril sodium (Standard) AHU-377 sodium (Standard)	Reference Standards Neprilysin	Infection Cardiovascular Disease
Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .

HY-P11642A

Sialorphin TFA	Enteropeptidase Aminopeptidase Opioid Receptor ERK mTOR Androgen Receptor	Inflammation/Immunology
Sialorphin TFA is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin TFA blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin TFA regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin TFA exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin TFA also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin TFA is also a copper (II) ion-binding ligand. Sialorphin TFA has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-19063

SCH-34826	Neprilysin	Cardiovascular Disease Others
SCH-34826 is an orally active neutral metalloendopeptidase (NEP) inhibitor that inhibits *NEP* and reduces the degradation of ANF, thereby enhancing its antihypertensive and diuretic effects. SCH-34826 can be used in the research of cardiovascular and renal diseases .

HY-15407AS1

Sacubitril-d4 hemicalcium salt AHU-377-d4 hemicalcium salt	Neprilysin Isotope-Labeled Compounds	Cardiovascular Disease
Sacubitril-d₄ hemicalcium salt is the deuterium labeled Sacubitril hemicalcium salt (HY-15407A). Sacubitril hemicalcium salt is a potent NEP inhibitor with an IC₅₀ of 5 nM .

HY-143886

AD011	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
AD011 is a dual inhibitor of *cACE/NEP*. AD011 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD011 has the potential for providing the potent antihypertensive and cardioprotective benefits .

HY-143888

AD013	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Others
AD013 is a dual inhibitor of *cACE/NEP*. AD013 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD013 has the potential for providing the potent antihypertensive and cardioprotective benefits .

HY-143887

AD012	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
AD012 is a dual inhibitor of *cACE/NEP*. AD012 is synthesized based on the previously reported C-domain selective ACE inhibitor lisinopril-tryptophan. AD012 has the potential for providing the potent antihypertensive and cardioprotective benefits .

HY-173430

AD015	Angiotensin-converting Enzyme (ACE) Neprilysin	Cardiovascular Disease Neurological Disease
AD015 is a angiotensin-converting enzyme (ACE) and neprilysin (NEP) dual inhibitor. AD015 inhibits NEP, nACE and cACE with IC₅₀s of 0.009, 0.019 and 0.0008 μM, respectively .

HY-P5754A

TAT-NEP1-40 TFA	Apoptosis	Neurological Disease
TAT-NEP1-40 TFA is a BBB-penatrable peptide. TAT-NEP1-40 TFA protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 TFA also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 TFA can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .

HY-17399S

Racecadotril-d5 Acetorphan-d₅	Isotope-Labeled Compounds Neprilysin	Metabolic Disease
Racecadotril-d₅ is the deuterium labeled Racecadotril. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with K_is of 4500 and 6.1 nM, , respectively. Antidiarrheal agent .

HY-114412A

TD-0212 TFA	Angiotensin Receptor Neprilysin	Cardiovascular Disease Inflammation/Immunology
TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT₁) antagonist and neprilysin (NEP) inhibitor, with a pK_i of 8.9 for AT₁ and a pIC₅₀ of 9.2 for NEP .

HY-114412

TD-0212	Angiotensin Receptor Neprilysin	Inflammation/Immunology Endocrinology
TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT₁) antagonist and neprilysin (NEP) inhibitor, with a pK_i of 8.9 for AT₁ and a pIC₅₀ of 9.2 for NEP .

HY-17399R

Racecadotril (Standard) Acetorphan (Standard)	Reference Standards Neprilysin	Metabolic Disease
Racecadotril (Standard) is the analytical standard of Racecadotril. This product is intended for research and analytical applications. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with K_is of 4500 and 6.1 nM, , respectively. Antidiarrheal agent .

HY-U00336

NEP-IN-2	Neprilysin	Cardiovascular Disease
NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the research of proliferation in atherosclerosis, restenosis.

HY-170962

SDUY817	Neprilysin Aminopeptidase	Neurological Disease
SDUY817 is a dual *APN/NEP* inhibitor, with IC₅₀ values of 0.29 μM for APN and 7.4 μM for *NEP*. SDUY817 exerts analgesic effects in a concentration- and time-dependent manner, and can be used for research in the field of neuropathic pain disorders .

HY-123150

UK-447841	Neprilysin	Endocrinology
UK-447841 is a selective *NEP* inhibitor. UK-447841 can be used in the research of female sexual arousal disorder .

HY-106975

SCH-42354	Neprilysin	Cardiovascular Disease
SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC₅₀ values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity .

HY-101682

SCH 42495	Neprilysin	Cardiovascular Disease
SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354 .

HY-W747097

Sacubitrilat-13C4 Desethyl Sacubitril-¹³C₄; LBQ-657-¹³C₄	Isotope-Labeled Compounds Neprilysin	Neurological Disease
Sacubitrilat- ¹³C₄ (Desethyl Sacubitril- ¹³C₄) is ¹³C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.

HY-170961

SDUY816	Aminopeptidase Neprilysin	Neurological Disease
SDUY816 is an oral active dual *APN/NEP* inhibitor, with IC₅₀ values of 0.68 μM for APN and 6.9 μM for *NEP*. SDUY816 exhibits analgesic effects and demonstrates good safety and pharmacokinetic profiles, with an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral administration, 10 mg/kg). SDUY816 has potential applications in the research of neuropathic pain disorders .

HY-114635

Dexecadotril Retorphan	Neprilysin	Metabolic Disease
Dexecadotril (Retorphan) is a powerful and selective neprilysin (NEP) inhibitor. Dexecadotril is a prodrug of the R-enantiomers of Thiorphan (HY-W013375). Dexecadotril shows intestinal antisecretatory action .

HY-123782

(Rac)-UK-414495	Neprilysin	Metabolic Disease
(Rac)-UK-414495 (example 7) is a potent neutral endopeptidase (NEP) inhibitor. (Rac)-UK-414495 causes potentiation of cAMP in the sexual genitalia of the female .

HY-101682A

SCH 42495 racemate	Neprilysin	Cardiovascular Disease
SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354 .

HY-139797

SCH 47896	Drug Derivative Neprilysin	Cardiovascular Disease
SCH 47896 is a phenolic derivative of SCH39370 (HY-139803), a potent specific inhibitor of metalloendopeptidase (NEP). SCH 47896 can be used for the research of cardiovascular disease, such as hypertension .

HY-144378S

Thiorphan methoxyacetophenone derivative-d7	Isotope-Labeled Compounds	Others
Thiorphan methoxyacetophenone derivative-d₇ is the deuterium labeled Thiorphan methoxyacetophenone derivative .

HY-172904

Antidiabetic agent 15	Angiotensin Receptor Neprilysin	Cardiovascular Disease Neurological Disease Metabolic Disease
Antidiabetic agent 15 (compound 1B15) is a AT1R and *NEP* dual inhibitor. Antidiabetic agent 15 reduces the oxidative stress and restores the mitochondrial membrane potential .

HY-19200

RB-105	Neprilysin Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
RB-105 is an inhibitor of angiotensin-converting enzyme (ACE) (K_i = 4.2 nM) and neutral endopeptidase (NEP) (K_i = 1.7 nM). RB-105 after inhibiting ACE reduces the production of Ang II and increase the level of bradykinin. RB-105 after inhibiting NEP increases the level of natriuretic peptide and further increases the level of bradykinin, thereby generating a powerful synergistic effect. RB-105 has significant antihypertensive and natriuretic effects in both spontaneously hypertensive rats and normal blood pressure rats. RB-105 can be used for research on hypertension .

HY-101682B

(R)-SCH 42495	Neprilysin	Cardiovascular Disease Others
(R)-SCH 42495 is the less active enantiomer of SCH 42495 . SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354 .

HY-114941

Aladotril BP1137	Angiotensin-converting Enzyme (ACE) Neprilysin	Cardiovascular Disease
Aladotril (BP1137) is the inhibitor for neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE), that ameliorates the cardiac hypertrophy in rats, without decreasing the blood pressure. Aladotril can be used in research about heart failure and cardiac remodeling after myocardial infarction .

Cat. No.	Product Name	Target	Research Area

HY-P3101

GLP-1(28-36)amide	GCGR	Cardiovascular Disease Metabolic Disease
GLP-1(28-36)amide, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide has anti-diabetic and cardioprotection effects .

HY-P5754

TAT-NEP1-40	Apoptosis	Neurological Disease
TAT-NEP1-40 is a BBB-penatrable peptide. TAT-NEP1-40 protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .

HY-P11642A

Sialorphin TFA	Enteropeptidase Aminopeptidase Opioid Receptor ERK mTOR Androgen Receptor	Inflammation/Immunology
Sialorphin TFA is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin TFA blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin TFA regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin TFA exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin TFA also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin TFA is also a copper (II) ion-binding ligand. Sialorphin TFA has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

HY-P5754A

TAT-NEP1-40 TFA	Apoptosis	Neurological Disease
TAT-NEP1-40 TFA is a BBB-penatrable peptide. TAT-NEP1-40 TFA protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 TFA also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 TFA can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .

HY-P3101A

GLP-1(28-36)amide TFA	GCGR	Cardiovascular Disease Metabolic Disease
GLP-1(28-36)amide TFA, a C-terminal nonapeptide of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide TFA is an antioxidant and targets to mitochondrion, inhibits mitochondrial permeability transition (MPT). GLP-1(28-36)amide TFA has anti-diabetic and cardioprotection effects .

HY-P11642

Sialorphin	ERK Androgen Receptor Opioid Receptor Enteropeptidase mTOR Aminopeptidase	Neurological Disease Inflammation/Immunology Cancer
Sialorphin is a neutral endopeptidase (NEP) and aminopeptidase N (APN) inhibitor that responds to androgen signals. Sialorphin blocks the degradation of endogenous opioid peptides and interacts with μ-, δ-, κ-opioid receptors. Sialorphin regulates the ERK/mTOR signaling pathway by inducing cell cycle arrest, enhancing ERK1/2 activity, and reducing the phosphorylation levels of mTOR, 4E-BP1, p70S6K; accordingly, Sialorphin exhibits antiproliferative activity against colorectal cancer, glioma and prostate cancer cells without cytotoxicity. In addition, Sialorphin also produces antinociceptive responses, regulates sexual behavior, relaxes corpus cavernosum smooth muscle, and alleviates experimental colitis. Sialorphin is also a copper (II) ion-binding ligand. Sialorphin has been used in mechanistic studies related to cancer, pain management and inflammatory bowel disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2021A

Phosphoramidon disodium	Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Source Classification Cancer	MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite
Phosphoramidon disodium, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC₅₀ of 0.4 μg/mL. Phosphoramidon disodium also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC₅₀ values of 3.5, 0.034, and 78 μM, respectively .

HY-N2021

Phosphoramidon	Microorganisms Ketones, Aldehydes, Acids	MMP Angiotensin-converting Enzyme (ACE) Neprilysin Endogenous Metabolite
Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC₅₀ of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC₅₀ values of 3.5, 0.034, and 78 μM, respectively .

HY-B1746R

Pyridoxamine 5′-phosphate (Standard)	Alkaloids Human Gut Microbiota Metabolites Pyridine Alkaloids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Sacubitril (sodium) (Standard) is the analytical standard of Sacubitril (sodium). This product is intended for research and analytical applications. Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .

Cat. No.	Product Name	Chemical Structure

HY-15407S

Sacubitril-d4
Sacubitril-d₄ is the deuterium labeled Sacubitril. Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril (AHU-377) is a component of the heart failure medicine LCZ696.

HY-17620S

Sacubitrilat-d4
Sacubitrilat-d₄ is the deuterium labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor .

HY-W013375S

Thiorphan-d7
Thiorphan-d₇ is the deuterium labeled Thiorphan . Thiorphan is a selective NEP (neprilysin) inhibitor with an IC₅₀ of 6.9 nM .

HY-15407AS1

Sacubitril-d4 hemicalcium salt
Sacubitril-d₄ hemicalcium salt is the deuterium labeled Sacubitril hemicalcium salt (HY-15407A). Sacubitril hemicalcium salt is a potent NEP inhibitor with an IC₅₀ of 5 nM .

HY-17399S

Racecadotril-d5
Racecadotril-d₅ is the deuterium labeled Racecadotril. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with K_is of 4500 and 6.1 nM, , respectively. Antidiarrheal agent .

HY-W747097

Sacubitrilat-13C4
Sacubitrilat- ¹³C₄ (Desethyl Sacubitril- ¹³C₄) is ¹³C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.

HY-144378S

Thiorphan methoxyacetophenone derivative-d7
Thiorphan methoxyacetophenone derivative-d₇ is the deuterium labeled Thiorphan methoxyacetophenone derivative .

HY-15407AS

Sacubitril-13C4 hemicalcium salt
Sacubitril- ¹³C₄ (hemicalcium salt) is a ¹³C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC₅₀ of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696 .

HY-78841S

(2S,4S)-Sacubitril-d4
(2S,4S)-Sacubitril-d₄ is deuterium labeled (2S,4S)-Sacubitril. (2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure .

HY-15407S3

Sacubitril-13C4
Sacubitril-13C4 (AHU-377-13C4) is a 13C-labeled version of Sacubitril (HY-15407). Sacubitril is an orally active inhibitor of neprilysin NEP (IC₅₀=5 nM). Sacubitril is used in research on heart failure, hypertension and COVID-19 .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks