1. Others Metabolic Enzyme/Protease
  2. Isotope-Labeled Compounds Neprilysin
  3. Sacubitril-13C4 hemicalcium salt

Sacubitril-13C4 hemicalcium salt  (Synonyms: AHU-377-13C4 hemicalcium salt)

Cat. No.: HY-15407AS
Handling Instructions

Sacubitril-13C4 (hemicalcium salt) is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696[1].

For research use only. We do not sell to patients.

Sacubitril-<sup>13</sup>C<sub>4</sub> hemicalcium salt Chemical Structure

Sacubitril-13C4 hemicalcium salt Chemical Structure

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Description

Sacubitril-13C4 (hemicalcium salt) is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

434.49

Formula

C2013C4H28Ca0.5NO5

SMILES

O=[13C]([13CH2][13CH2][13C]([O-])=O)N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@@H](C)C(OCC)=O.[0.5Ca2+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Sacubitril-13C4 hemicalcium salt Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Sacubitril-13C4 hemicalcium salt
Cat. No.:
HY-15407AS
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