CGS 35601
CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats.
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- CAS No.: 849066-09-7
- Formula: C23H31N3O4S
- Molecular Weight:445.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 55 nM (ECE-1), 2 nM (NEP), 22 nM (ACE)
Chemical Information
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CAS No. 849066-09-7
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Molecular Weight 445.58
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Formula C23H31N3O4S
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SMILES
CC(C)C[C@H](S)C(NC1(CCCC1)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGS 35601 Related Classifications
HY-18211 Related Classifications
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