849066-09-7
Chemical Structure
CGS 35601
- CAS No.: 849066-09-7
- Formula:C23H31N3O4S
- Molecular Weight:445.58
IUPAC Name: (S)-3-(1H-indol-3-yl)-2-(1-((S)-2-mercapto-4-methylpentanamido)cyclopentanecarboxamido)propanoic acid
InChIKey: YFAHICISBQLBQH-OALUTQOASA-N
SMILES: CC(C)C[C@H](S)C(NC1(CCCC1)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(O)=O)=O)=O
Biological Activity: CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats[1].
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CGS 35601 | CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats. | |||||||||||||||||||||
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Keywords
