1. Metabolic Enzyme/Protease
  2. Neprilysin
  3. SCH 42495

SCH 42495 

Cat. No.: HY-101682
Handling Instructions

SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354.

For research use only. We do not sell to patients.

SCH 42495 Chemical Structure

SCH 42495 Chemical Structure

CAS No. : 136511-43-8

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Description

SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354[1].

IC50 & Target

NEP[1]

In Vitro

SCH 42354 selectively inhibits hydrolysis of leu-enkephalin and ANF (IC50 of 8.3 and 10.0 nM, respectively) in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SCH 42495 (30 mg/kg; oral gavage; twice daily) causes a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days[2].
Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats[2].
SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hypoxic rats[2]
Dosage: 30 mg/kg
Administration: Oral gavage; twice daily for 10 days
Result: Caused a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy.
Led to a decrease in cardiovascular remodelling secondary to chronic hypoxia.
Molecular Weight

411.58

Formula

C₂₀H₂₉NO₄S₂

CAS No.

136511-43-8

SMILES

CSCC[[email protected]@H](C(OCC)=O)NC([[email protected]@H](CSC(C)=O)CC1=CC=CC=C1C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SCH 42495SCH42495SCH-42495NeprilysinNeutral endopeptidaseNEPCluster of differentiation 10CD10chronichypoxianeutralendopeptidasepulmonaryhypertensionvascularremodellingInhibitorinhibitorinhibit

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SCH 42495
Cat. No.:
HY-101682
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