Search Result

Results for "

Nucleoside derivatives

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Nucleoside Antimetabolite/Analog (24) Nucleoside Transporters (2) Adenosine Receptor (1) Androgen Receptor (1) Antibiotic (4) Apoptosis (1) Autophagy (2) Bacterial (3) CMV (1) DNA/RNA Synthesis (12) Drug Derivative (2) Drug Intermediate (4) Endogenous Metabolite (2) Filovirus (1) Fungal (1) HBV (2) HCV (3) HIV (6) IFNAR (2) Isotope-Labeled Compounds (4) MMP (2) Phosphodiesterase (PDE) (1) Phosphoramidites (6) Reference Standards (5) Reverse Transcriptase (1) SARS-CoV (1) TNF Receptor (2)
By Research Areas:	Cancer (12) Infection (23) Inflammation/Immunology (2) Metabolic Disease (5) Neurological Disease (2)
Click Chemistry:	Azide (2)
Oligonucleotides:	Adenosine (1) Guanosine (5) Thymine (1) Nucleoside Analogs (8) Hypoxanthine (1) Thymidine (1) Uracil (2) Phosphoramidites (5) Guanine (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Amino Acid Derivatives Nucleoside Transporters Nucleoside Antimetabolite/Analog NTPDase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0262

Cordycepin 10+ Cited Publications 3'-Deoxyadenosine	TNF Receptor MMP Bacterial Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills *Mycobacterium tuberculosis* through hijacking the bacterial adenosine kinase .

HY-20140

5'-O-DMT-dT 5'-O-(4,4'-Dimethoxytrityl)thymidine	Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Others
5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides .

HY-W019033

8-Bromoguanosine	Nucleoside Antimetabolite/Analog	Others
8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .

HY-W008662

2'-Deoxy-5'-O-DMT-2'-fluorouridine 1 Publications Verification	Phosphoramidites Filovirus	Infection
2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity .

HY-104014

DMT-2'O-MOE-rG(ib) Phosphoramidite	Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Others
DMT-2'O-MOE-rG(ib) Phosphoramidite belongs to cyanoethyl-protected nucleoside phosphoramidites. DMT-2'O-MOE-rG(ib) Phosphoramidite is a derivative of nucleotide and guanosine. DMT-2'O-MOE-rG(ib) Phosphoramidite can be used for the stereochemical synthesis of phosphorothioate oligonucleotides .

HY-W003486

5,7-Dichloropyrazolo[1,5-a]pyrimidine	Phosphodiesterase (PDE)	Neurological Disease Cancer
5,7-Dichloropyrazolo[1,5-a]pyrimidine is a PDE10A inhibitor with a K_i of 24 μM. 5,7-Dichloropyrazolo[1,5-a]pyrimidine serves as a key intermediate in the synthesis of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives (HIV-1 non-nucleoside reverse transcriptase inhibitors). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used for the research of schizophrenia .

HY-W013403

2'-Deoxy-2'-fluorouridine	IFNAR	Infection
2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .

HY-120832

Azt-pmap	HIV	Infection
Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity . AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection . Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-111531

DMTr-LNA-5MeU-3-CED-phosphoramidite	Phosphoramidites Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
DMTr-LNA-5MeU-3-CED-phosphoramidite is a Phosphoramidite derivative and **Nucleoside derivative** .

HY-W010744

DMT-dI 5'-O-DMT-dI; 2'-Deoxy-5'-O-DMT-inosine	Phosphoramidites Nucleoside Antimetabolite/Analog	Cancer
DMT-dI (5'-O-DMT-dI) is a deoxyribonucleoside containing a hypoxanthine base. DMT-dI can be used to prepare convertible nucleoside derivatives to prepare modified oligonucleotides complementary to target genes for gene editing. DMT-dI can be used to study various conditions, disorders or diseases modified by adenosine .

HY-W013330

3′-Deoxyguanosine Guanosine, 3'-deoxy-	Nucleoside Antimetabolite/Analog Drug Derivative	Metabolic Disease
3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human *purine nucleoside* phosphorylase** via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [ ³H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism .

HY-14941

Elacytarabine 1 Publications Verification CP 4055	Nucleoside Antimetabolite/Analog	Cancer
Elacytarabine (CP 4055) is a lipid-conjugated derivative of the nucleoside analog cytarabine. Elacytarabine (CP 4055) is an antineoplastic agent with cytotoxicity in solid tumors.

HY-13465

VCH-916 1 Publications Verification	HCV	Infection
VCH-916 is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase with sub-micromolar IC₅₀ values versus genotype 1a and 1b replicons. VCH-916 binds to Thumb Site II. VCH-916 can be used for the research of hepatitis c virus (hcv) infection .

HY-100028

AT-130 2 Publications Verification	HBV DNA/RNA Synthesis	Infection Cancer
AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC₅₀ of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells .

HY-N0262R

Cordycepin (Standard) 3'-Deoxyadenosine (Standard)	TNF Receptor Reference Standards MMP Bacterial Autophagy Antibiotic	Infection Inflammation/Immunology Cancer
Cordycepin (Standard) is the analytical standard of Cordycepin. This product is intended for research and analytical applications. Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .

HY-41344

Ganciclovir mono-O-acetate	Antibiotic	Infection
Ganciclovir mono-O-acetate is a derivative of Ganciclovir. Ganciclovir, a nucleoside analogue, is an orally active antiviral agent with activity against CMV .

HY-W001957

Glurate 4-Acetylbutyric acid; 5-Oxohexanoic acid; NSC-5281	Drug Intermediate HIV	Infection
Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .

HY-W054064

6-Chloro-7-deazapurine-β-D-riboside	Fungal	Infection
6-Chloro-7-deazapurine-β-D-riboside, a nucleoside derivative, exerts antifungal effects. 6-Chloro-7-deazapurine-β-D-riboside shows activity against plant pathogenic fungi .

HY-W008388

Bz-rA N6-Benzoyladenosine	Nucleoside Antimetabolite/Analog	Others
Bz-rA (N6-Benzoyladenosine) is a nucleoside derivative with an N6 protecting group. Bz-rA is mainly used as a synthetic intermediate to participate in photocatalytic oxidative cyclization reactions and synthesize oligoribonucleotides. Bz-rA can be used to efficiently construct heterocyclic skeletons in photochemical conversions and protect the ribose moiety to regulate the cyclization pathway .

HY-111807

Locked nucleic acid 1	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Metabolic Disease
Locked nucleic acid 1 is a derivative of LNA-type nucleoside.

HY-W586082

N-Isobutyryl-2', 3'-acetyl-guanosine	Nucleoside Antimetabolite/Analog	Others
N-Isobutyryl-2',3'-Acetyl-Guanosine is a guanosine nucleoside derivative.

HY-W073825

N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine	Nucleoside Antimetabolite/Analog	Cancer
N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a 2’-0-(2-methoxyethyl) guanosine derivative. 2’-0-methoxyethyl nucleoside derivatives can enhance the affinity with RNA and increase the resistance of oligonucleotides to nucleases.

HY-177747

dMeThPmR	Nucleoside Transporters	Cancer
dMeThPmR, a ribonucleoside derivative, is a potent and selective *human nucleoside* transporter 1 (hCNT1) inhibitor (K_i = 0.3-0.98 μM). dMeThPmR exhibit weak inhibitory activity on hCNT2 (IC₅₀ = 133 μM) and hCNT3 (K_i** = 32.7 μM). dMeThPmR can protect cells from the toxicity of nucleoside drugs. dMeThPmR can be used for the research of cancer .

HY-177746

MeThPmR	Nucleoside Transporters	Cancer
MeThPmR, a ribonucleoside derivative, is a potent and selective *human nucleoside* transporter 1 (hCNT1) inhibitor (K_i/sub> = 0.16-0.69 μM). MeThPmR exhibit weak inhibitory activity on hCNT2 (IC₅₀ = 360 μM) and hCNT3 (K_i** = 4.7 μM). MeThPmR can protect cells from the toxicity of nucleoside drugs. MeThPmR can be used for the research of cancer .

HY-153062

6-Chloro-7-deazapurine-2F-β-D-arabinofuranose	HCV	Infection
6-Chloro-7-deazapurine-2F-β-D-arabinofuranose is a nucleoside derivative. 6-Chloro-7-deazapurine-2F-β-D-arabinofuranose can be used for synthesis of antiviral agent against hepatitis C virus infection .

HY-111642

3'-Azido-3'-deoxy-beta-L-uridine	Nucleoside Antimetabolite/Analog	Others
3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative. 3'-Azido-3'-deoxy-beta-L-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-15350

Trovirdine hydrochloride LY 300046 hydrochloride	Reverse Transcriptase	Others
Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells .

HY-172003

Isoorotidine	Nucleoside Antimetabolite/Analog	Metabolic Disease
Isoorotidine is a nucleoside derivative and an isomer of the pyrimidine nucleoside Orotidine (HY-113226).

HY-155291

3'-Mant-GDP	Others	Others
3'-Mant-GDP is a nucleoside compound and a derivative of guanosine diphosphate .

HY-137693

ddTTPαS	Nucleoside Antimetabolite/Analog	Others
ddTTPαS is a sulfur-containing nucleoside triphosphate derivative. ddTTPαS can be used for chain extension in PCR assays .

HY-137693A

ddTTPαS tetrasodium	Nucleoside Antimetabolite/Analog	Others
ddTTPαS tetrasodium is a sulfur-containing nucleoside triphosphate derivative. ddTTPαS tetrasodium can be used for chain extension in PCR assays .

HY-152294

3′-Deoxy-3′-methyluridine	DNA/RNA Synthesis	Infection
3′-Deoxy-3′-methyluridine is a nucleoside derivative, involving in preparation inhibitors of RNA-dependent RNA viral polymerase .

HY-159737

Rociclovir HOE 602	HCV CMV	Infection
Rociclovir (HOE 602) is an acyclic nucleoside derivative. Rociclovir protects mice against HSV and MCMV infections, but lacks antiviral activity in cell cultures .

HY-172027

Remdesivir methylpropyl ester analog GS-5734 methylpropyl ester analog	SARS-CoV	Infection
Remdesivir methylpropyl ester analog (GS-5734 methylpropyl ester analog) is a derivative of Remdesivir (HY-104077). Remdesivir is a nucleoside analogue with effective antiviral activity.

HY-138594

5'-O-TBDMS-N2-ibu-dG	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
5'-O-TBDMS-N2-ibu-dG is a **nucleoside derivative** and can be used for lead compounds synthesis with anti-bovine viral diarrhea virus activity .

HY-W048502

8-Mercaptoadenosine 8-Thioadenosine	Drug Intermediate	Others
8-Mercaptoadenosine is a nucleoside derivative that can be synthesized in DMF-aqueous solution at room temperature using NaSH via the corresponding 8-bromo compounds, and it is an intermediate in the synthesis of the substrate for RNA pyrophosphorylase .

HY-134272A

8-Bromo-2'-deoxy-ATP tetrasodium 8-Bromo-dATP tetrasodium	Endogenous Metabolite	Metabolic Disease
8-Bromo-2'-deoxy-ATP (8-Bromo-dATP) tetrasodium is a derivative of the nucleoside triphosphate 2'-Deoxyadenosine-5'-triphosphate (dATP, HY-136648).

HY-131804A

3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate tetrasodium 3'-O-Ac-dCTP tetrasodium	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate (3'-O-Ac-dCTP) tetrasodium is a nucleoside triphosphate derivative with potential applications in DNA synthesis and nucleoside drug design. 3'-O-Acetyl-2'-deoxycytidine-5'-O-triphosphate tetrasodium can be used to inhibit chain elongation reactions and as a terminator or biochemical probe .

HY-41344R

Ganciclovir mono-O-acetate (Standard)	Antibiotic Reference Standards	Infection
Ganciclovir mono-O-acetate (Standard) is the analytical standard of Ganciclovir mono-O-acetate. This product is intended for research and analytical applications. Ganciclovir mono-O-acetate is a derivative of Ganciclovir. Ganciclovir, a nucleoside analogue, is an orally active antiviral agent with activity against CMV[1].

HY-W751961

2'-Deoxyadenosine-15N5	Isotope-Labeled Compounds Endogenous Metabolite	Others
2'-Deoxyadenosine-15N5 is the ¹⁵N₅-labeled version of 2'-Deoxyadenosine (HY-W040329). 2'-Deoxyadenosine is a nucleoside adenosine derivative that can pair with deoxythymidine in double-stranded DNA.

HY-W747965

8-Bromoguanosine-13C2,15N	Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog	Others
8-Bromoguanosine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .

HY-W767371

8-Bromoguanosine-13C,15N2	Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog	Others
8-Bromoguanosine- ¹³C, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .

HY-W001957R

Glurate (Standard) 4-Acetylbutyric acid (Standard); 5-Oxohexanoic acid (Standard); NSC-5281 (Standard)	Reference Standards Drug Intermediate HIV	Infection
Glurate (Standard) is the analytical standard of Glurate (HY-W001957). This product is used for research and analytical applications. Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .

HY-163978

YGZ-331	Adenosine Receptor	Neurological Disease
YGZ-331 is a sedative with a calming effect. YGZ-331 is a derivative of the adenosine nucleoside NGBA, which can increase GABA levels. YGZ-331 exerts a sedative-hypnotic effect by activating A1R and A2aR, and inhibiting CaMKII phosphorylation (pCaMKII) levels. YGZ-331 can reduce the spontaneous motor activity of mice .

HY-W701362

Glurate-d5 4-Acetylbutyric acid-d₅; 5-Oxohexanoic acid-d₅; NSC-5281-d₅	Isotope-Labeled Compounds HIV Drug Intermediate	Infection
Glurate-d₅ (4-Acetylbutyric acid-d₅; 5-Oxohexanoic acid-d₅; NSC-5281-d₅) is the deuterium labeled Glurate (HY-W001957). Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .

HY-W013403S

2'-Deoxy-2'-fluorouridine-d2	IFNAR	Infection
2'-Deoxy-2'-fluorouridine-d₂ is the deuterium labeled 2'-Deoxy-2'-fluorouridine . 2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .

HY-131805A

3'-O-Ac-dGTP sodium	Drug Derivative	Metabolic Disease
3'-O-Ac-dGTP sodium is an acetylated derivative of the nucleoside triphosphate 2'-deoxyguanosine-5'-triphosphate .

HY-183641

5'-O-DMTr-N,N-Dimethylacetamide-dA-3'-CE phosphoramidite	Phosphoramidites DNA/RNA Synthesis	Others
5'-O-DMTr-N,N-Dimethylacetamide-dA-3'-CE phosphoramidite (Compound 16a) is a Phosphoramidite derivative. 5'-O-DMTr-N,N-Dimethylacetamide-dA-3'-CE phosphoramidite can be used in studies related to the introduction of N-alkyl nucleosides into DNA oligonucleotides .

HY-182991

2′-O-Hexyl-adenosine	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O-Hexyl-adenosine is a nucleoside derivative that can be used for the synthesis of RNA .

HY-131806A

3'-O-Ac-dTTP sodium	Nucleoside Antimetabolite/Analog	Others
3'-O-Ac-dTTP sodium is an acetylated derivative of nucleoside 5′-triphosphate .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0262

Cordycepin 10+ Cited Publications 3'-Deoxyadenosine	Infection Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification Cancer	TNF Receptor MMP Bacterial Autophagy Antibiotic
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills *Mycobacterium tuberculosis* through hijacking the bacterial adenosine kinase .

HY-N0262R

Cordycepin (Standard) 3'-Deoxyadenosine (Standard)	Structural Classification Natural Products Microorganisms Source Classification	TNF Receptor Reference Standards MMP Bacterial Autophagy Antibiotic
Cordycepin (Standard) is the analytical standard of Cordycepin. This product is intended for research and analytical applications. Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase .

HY-N19781

Kipukasin B	Structural Classification Monophenols Microorganisms Phenols Source Classification	Bacterial
Kipukasin B is an antibacterial agent. Kipukasin B exhibits activity against the Gram-positive strain Bacillus subtilis. Kipukasin B is isolated from Aspergillus versicolor obtained from Hawaii. Kipukasin B can be used in the research of Gram-positive bacterial infections .

Cat. No.	Product Name	Chemical Structure

HY-W751961

2'-Deoxyadenosine-15N5
2'-Deoxyadenosine-15N5 is the ¹⁵N₅-labeled version of 2'-Deoxyadenosine (HY-W040329). 2'-Deoxyadenosine is a nucleoside adenosine derivative that can pair with deoxythymidine in double-stranded DNA.

HY-W747965

8-Bromoguanosine-13C2,15N
8-Bromoguanosine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .

HY-W767371

8-Bromoguanosine-13C,15N2
8-Bromoguanosine- ¹³C, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .

HY-W701362

Glurate-d5

Glurate-d₅ (4-Acetylbutyric acid-d₅; 5-Oxohexanoic acid-d₅; NSC-5281-d₅) is the deuterium labeled Glurate (HY-W001957). Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .

HY-W013403S

2'-Deoxy-2'-fluorouridine-d2

2'-Deoxy-2'-fluorouridine-d₂ is the deuterium labeled 2'-Deoxy-2'-fluorouridine . 2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .

Cat. No.	Product Name		Classification

HY-120832

Azt-pmap		Azide
Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity . AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection . Azt-pmap is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-111642

3'-Azido-3'-deoxy-beta-L-uridine		Azide
3'-Azido-3'-deoxy-beta-L-uridine (Compound 25) is a nucleoside derivative. 3'-Azido-3'-deoxy-beta-L-uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-20140

5'-O-DMT-dT 5'-O-(4,4'-Dimethoxytrityl)thymidine		Phosphoramidites Thymine
5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides .

HY-W019033

8-Bromoguanosine		Nucleoside Analogs Guanosine
8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .

HY-W008662

2'-Deoxy-5'-O-DMT-2'-fluorouridine 1 Publications Verification		Phosphoramidites Uracil
2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity .

HY-104014

DMT-2'O-MOE-rG(ib) Phosphoramidite		Phosphoramidites Guanine
DMT-2'O-MOE-rG(ib) Phosphoramidite belongs to cyanoethyl-protected nucleoside phosphoramidites. DMT-2'O-MOE-rG(ib) Phosphoramidite is a derivative of nucleotide and guanosine. DMT-2'O-MOE-rG(ib) Phosphoramidite can be used for the stereochemical synthesis of phosphorothioate oligonucleotides .

HY-111531

DMTr-LNA-5MeU-3-CED-phosphoramidite		Phosphoramidites Uracil
DMTr-LNA-5MeU-3-CED-phosphoramidite is a Phosphoramidite derivative and **Nucleoside derivative** .

HY-W010744

DMT-dI 5'-O-DMT-dI; 2'-Deoxy-5'-O-DMT-inosine		Phosphoramidites Hypoxanthine
DMT-dI (5'-O-DMT-dI) is a deoxyribonucleoside containing a hypoxanthine base. DMT-dI can be used to prepare convertible nucleoside derivatives to prepare modified oligonucleotides complementary to target genes for gene editing. DMT-dI can be used to study various conditions, disorders or diseases modified by adenosine .

HY-W013330

3′-Deoxyguanosine Guanosine, 3'-deoxy-		Nucleoside Analogs Guanosine
3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human *purine nucleoside* phosphorylase** via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [ ³H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism .

HY-W054064

6-Chloro-7-deazapurine-β-D-riboside		Nucleoside Analogs
6-Chloro-7-deazapurine-β-D-riboside, a nucleoside derivative, exerts antifungal effects. 6-Chloro-7-deazapurine-β-D-riboside shows activity against plant pathogenic fungi .

HY-111807

Locked nucleic acid 1		Nucleoside Analogs Thymidine
Locked nucleic acid 1 is a derivative of LNA-type nucleoside.

HY-W586082

N-Isobutyryl-2', 3'-acetyl-guanosine		Nucleoside Analogs Guanosine
N-Isobutyryl-2',3'-Acetyl-Guanosine is a guanosine nucleoside derivative.

HY-W073825

N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine		Nucleoside Analogs Guanosine
N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a 2’-0-(2-methoxyethyl) guanosine derivative. 2’-0-methoxyethyl nucleoside derivatives can enhance the affinity with RNA and increase the resistance of oligonucleotides to nucleases.

HY-138594

5'-O-TBDMS-N2-ibu-dG		Nucleoside Analogs Guanosine
5'-O-TBDMS-N2-ibu-dG is a **nucleoside derivative** and can be used for lead compounds synthesis with anti-bovine viral diarrhea virus activity .

HY-W048502

8-Mercaptoadenosine 8-Thioadenosine		Nucleoside Analogs Adenosine
8-Mercaptoadenosine is a nucleoside derivative that can be synthesized in DMF-aqueous solution at room temperature using NaSH via the corresponding 8-bromo compounds, and it is an intermediate in the synthesis of the substrate for RNA pyrophosphorylase .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Nucleoside derivatives

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Natural
Products