1. Anti-infection
  2. HIV
  3. Azt-pmap

Azt-pmap 

Cat. No.: HY-120832
Handling Instructions

Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity. AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection.

For research use only. We do not sell to patients.

Azt-pmap Chemical Structure

Azt-pmap Chemical Structure

CAS No. : 142629-81-0

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Description

Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity[1]. AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection[2].

IC50 & Target

HIV-1

 

In Vitro

Azt-pmap shows anti-HIV-1 activities in infected C8166 and JM cells with EC50s of 0.08 and0.32 μM, respectively. Azt-pmap displays toxicities in infected C8166 and JM cells with TC50s of 500 μM, respectively. Azt-pmap inhibits virus replication[1].

Molecular Weight

508.42

Formula

C₂₀H₂₅N₆O₈P

CAS No.

142629-81-0

SMILES

O=C(NC1=O)N(C=C1C)[[email protected]@H]2O[[email protected]](COP(OC3=CC=CC=C3)(N[[email protected]@H](C)C(OC)=O)=O)[[email protected]@H](N=[N+]=[N-])C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Azt-pmapHIVHuman immunodeficiency virusderivativeHIV1virusreplicationtoxicitiesinfectionnucleosideanalogueInhibitorinhibitorinhibit

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Azt-pmap
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