RDEA-427

Cat. No.: HY-111147: Data Sheet Handling Instructions
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RDEA-427 is a pyrrolopyrimidine derivative and also a HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). RDEA-427 acts on wild-type and NNRTI-resistant mutant HIV-1. RDEA-427 can be used in research related to HIV infection.

For research use only. We do not sell to patients.

RDEA-427 Chemical Structure

CAS No. : 914496-19-8

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

HIV-1

In Vitro

RDEA-427 (for 5 days) potently inhibits the replication of wild-type HIV-1 in MT4 cells, with an EC₅₀ of 0.9 nM and SI >50,000^[1].
RDEA-427 (for 5 days) inhibits the replication of NNRTI-resistant HIV-1^K103N-Y181C mutant strain in MT4 cells, and the EC₅₀ value against this mutant was 11‑fold higher than that against the wild‑type strain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

380.41

Formula

C₂₂H₁₆N₆O

CAS No.

914496-19-8

SMILES

N#CC1=CC=C(C=C1)NC=2N=C(OC=3C(=CC(C#N)=CC3C)C)C=4C=CNC4N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tian Y, et al. Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives. Bioorg Med Chem. 2014 Apr 1;22(7):2052-9. [Content Brief]

RDEA-427 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RDEA-427914496-19-8RDEA427RDEA 427HIVHuman immunodeficiency viruswild-type HIV-1K103N-Y181C HIV-1 mutantHIV-1 non-nucleoside reverse transcriptase inhibitorNNRTI-resistant mutant HIV-1HIV infectionMT4 cellsInhibitorinhibitorinhibit

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