Trovirdine hydrochloride
Based on 1 publication(s) in Google Scholar
Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells.
For research use only. We do not sell to patients.
- CAS No.: 148311-89-1
- Formula: C13H14BrClN4S
- Molecular Weight:373.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Trovirdine hydrochloride
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | CC50 |
60 μM
Compound: Trovirdine
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Cytotoxic concentration required to reduce the viability of mock infected MT-4 cells determined by MTT method
Cytotoxic concentration required to reduce the viability of mock infected MT-4 cells determined by MTT method
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[PMID: 15916438] |
| MT4 | EC50 |
0.02 μM
Compound: Trovirdine
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Effective concentration require to protect MT-4 cells from human immunodeficiency virus type 1 induced cytopathogenicity was determined by MTT method
Effective concentration require to protect MT-4 cells from human immunodeficiency virus type 1 induced cytopathogenicity was determined by MTT method
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[PMID: 15916438] |
| MT4 | EC50 |
1.2 μM
Compound: Trovirdine
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Effective concentration require to protect MT-4 cells from HIV-1 Y181C mutant induced cytopathogenicity was determined by MTT method
Effective concentration require to protect MT-4 cells from HIV-1 Y181C mutant induced cytopathogenicity was determined by MTT method
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[PMID: 15916438] |
| MT4 | IC50 |
0.8 μM
Compound: Trovirdine
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Potency against non nucleoside reverse transcriptor was determined in MT-4 cells
Potency against non nucleoside reverse transcriptor was determined in MT-4 cells
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[PMID: 15109677] |
Chemical Information
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CAS No. 148311-89-1
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Molecular Weight 373.70
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Formula C13H14BrClN4S
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SMILES
S=C(NCCC1=NC=CC=C1)NC2=NC=C(Br)C=C2.Cl
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Synonyms
LY 300046 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Antimicrob Agents
2019 Dec;54(6):814-819. PMID: 31479744
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trovirdine hydrochloride Related Classifications
HY-15350 Related Classifications
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