148311-89-1
Chemical Structure
Trovirdine hydrochloride
Synonym(s): LY 300046 hydrochloride
- CAS. Nr.: 148311-89-1
- Formula:C13H14BrClN4S
- Molecular Weight:373.70
IUPAC Name: 1-(5-bromopyridin-2-yl)-3-(2-(pyridin-2-yl)ethyl)thiourea hydrochloride
InChIKey: IUQKLSJRANLIKE-UHFFFAOYSA-N
SMILES: S=C(NCCC1=NC=CC=C1)NC2=NC=C(Br)C=C2.Cl
Biological Activity: Trovirdine hydrochloride (LY300046 hydrochloride) is a selective non-nucleoside HIV-1 reverse transcriptase inhibitor, with an IC50 value of 0.012 μM against the wild-type enzyme. Trovirdine hydrochloride inhibits the replication of both wild-type and mutant HIV-1, and exerts synergistic or additive effects when combined with some antiviral drugs. Trovirdine hydrochloride is applicable to research related to HIV-1 infection[1].
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Trovirdine hydrochloride | Trovirdine hydrochloride (LY300046 hydrochloride) is a selective non-nucleoside HIV-1 reverse transcriptase inhibitor, with an IC50 value of 0.012 μM against the wild-type enzyme. Trovirdine hydrochloride inhibits the replication of both wild-type and mutant HIV-1, and exerts synergistic or additive effects when combined with some antiviral drugs. Trovirdine hydrochloride is applicable to research related to HIV-1 infection. | |||||||||||||||||||||
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