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Results for "

RAR-α

" in MedChemExpress (MCE) Product Catalog:

標的別:	RAR/RXR (48) AP-1 (1) Apoptosis (11) Autophagy (17) Cytochrome P450 (1) Drug Derivative (1) Isotope-Labeled Compounds (3) PROTACs (1) Reference Standards (11) SNIPERs (1) Thyroid Hormone Receptor (1) TRP Channel (1) UGT (1) VD/VDR (1)
研究分野別:	Cancer (36) Endocrinology (1) Infection (1) Inflammation/Immunology (12) Metabolic Disease (4) Neurological Disease (11)

阻害剤およびアゴニスト

蛍光色素

生化学アッセイ試薬

同位体標識化合物

Targets Recommended: RAR/RXR ROR

製品番号	製品名	Target	研究分野	構造式

HY-10475

AM580 Maximum Cited Publications 14 Publications Verification CD336; NSC608001; Ro 40-6055	RAR/RXR Autophagy	Cancer
AM580 is a selective *RARα* agonist with IC₅₀ and EC₅₀ of 8 nM and 0.36 nM, respectively.

HY-14652

Tamibarotene 5+ Cited Publications Am 80	RAR/RXR Autophagy Apoptosis	Cancer
Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RARγ.

HY-U00449

AGN 193109 5+ Cited Publications	RAR/RXR	Cancer
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with K_ds of 2 nM, 2 nM, and 3 nM for *RARα, RARβ, and RAR*γ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-100256

Trifarotene CD5789	RAR/RXR Autophagy	Inflammation/Immunology
Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ～65-fold and ～16-fold selectivitiy for the RARγ (EC₅₀=7.7 nM) over *RARα* (EC₅₀=500 nM) and RARβ (EC₅₀=125 nM), respectively .

HY-B0091

Adapalene 5 Publications Verification CD271	RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent *RAR* agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, *RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1* in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-116248

Ro 41-5253 3 Publications Verification	RAR/RXR Apoptosis	Cancer
Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity .

HY-101106

AR7 10+ Cited Publications	RAR/RXR	Neurological Disease Cancer
AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy .

HY-107397

Ch55 2 Publications Verification	RAR/RXR	Cancer
Ch55 is a potent synthetic retinoid. Ch55 binds to *RAR-α* and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC₅₀ of 200 nM. Ch55 can be used for cancer research .

HY-107436

LE135 4 Publications Verification	RAR/RXR TRP Channel	Neurological Disease Cancer
LE135 is a potent RAR antagonist that binds selectively to *RARα* (K_i of 1.4 μM) and RARβ (K_i of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent TRPV1 and TRPA1 receptors activator with EC₅₀s of 2.5 μM and 20 μM, respectively .

HY-107395

BMS 753	RAR/RXR	Inflammation/Immunology
BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a K_i of 2 nM .

HY-16684

AGN-195183 IRX-5183; VTP-195183; NRX-195183	RAR/RXR Autophagy	Cancer
AGN-195183 (IRX-5183) is a potent and selective agonist of *RARα* (K_d=3 nM) with improved binding selectivity relative to AGN 193836. AGN-195183 has no activity on RARβ/γ.

HY-16683

AGN 205728	RAR/RXR Autophagy	Cancer
AGN 205728 is a potent and selective RARγ antagonist with K_i/IC₉₅ values of 3 nM/0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 can inhibit abnormal proliferation of leukemia cells .

HY-16681

AGN 194310 5+ Cited Publications VTP-194310	RAR/RXR Autophagy	Cancer
AGN 194310 (VTP-194310) is a high affinity, potent and selective retinioic acid receptors (RARs) pan-antagonist with K_d values of 3 nM, 2 nM, 5 nM for *RARα, RARβ, RAR*γ, respectively . AGN 194310 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-125904

4-Hydroxyretinoic acid 1 Publications Verification	RAR/RXR UGT Cytochrome P450 Apoptosis Drug Derivative	Neurological Disease Inflammation/Immunology Cancer
4-Hydroxyretinoic acid (4-HRA) is a derivative of Retinoic acid (HY-14649). 4-Hydroxyretinoic acid is formed via the catalysis of retinol by cytochrome P-450 isoenzymes. 4-Hydroxyretinoic acid also serves as a substrate for UDP-glucuronosyltransferase (s) and recombinant UGT2B7. 4-Hydroxyretinoic acid binds to the nuclear receptor *RAR* (Retinoic Acid Receptor), activates RAR and RXR-alpha, subsequently regulates gene expression and cell differentiation, and induces cancer cell apoptosis (Apoptosis). 4-Hydroxyretinoic acid also participates in multiple physiological processes such as immunoregulation, neuroprotection and antioxidation .

HY-16682

AGN 196996 3 Publications Verification	RAR/RXR Autophagy	Cancer
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).

HY-108530

MM11253	RAR/RXR	Cancer
MM11253 is a potent and selective RARγ antagonist with an IC₅₀ of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists .

HY-111573

KCL-286 C286	RAR/RXR	Others Neurological Disease Inflammation/Immunology
KCL-286 (C286) is an orally active and brain-penetrant *retinoic acid receptor (RAR) β2* agonist (EC₅₀ = 1.9 nM). KCL-286 targets RARβ2 with good selectivity over RAR α (EC₅₀ = 26 nM) and RAR γ (EC₅₀ = 11 nM). KCL-286 activates RARβ2 in the injured neurons. KCL-286 induces axonal regeneration of both spinal and sensory nerves through the inhibitory environment of the CNS, modulates neuroinflammation and extracellular matrix molecules. KCL-286 can modulate the expression of CSPGs by neuronal secretion of decorin which promotes myelination and aids axonal growth. KCL-286 can be studied in research for area such as spinal cord injury and traumatic nerve injury .

HY-14653

Amsilarotene TAC-101; Am 555S	RAR/RXR Apoptosis	Cancer
Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with K_i of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer .

HY-119518

BMS641 BMS-209641	RAR/RXR	Cancer
BMS641 (BMS-209641) is a selective RARβ agonist. BMS641 has a higher affinity for RARβ (K_d, 2.5 nM) that is 100 times higher than that for RARα (K_d, 225 nM) or RARγ (K_d, 223 nM) .

HY-156280

RARα antagonist 1	RAR/RXR	Endocrinology
RARα antagonist 1 (compound 21) is an orally active and selective retinoic acid receptor α(RARα) antagonist, with the IC₅₀ of 4.6nM .

HY-127024

Thyroid hormone receptor antagonist (1-850)	Thyroid Hormone Receptor	Metabolic Disease
Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC₅₀ of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. Thyroid hormone receptor antagonist (1-850) has no effect on the activity of RARα .

HY-108531

ER 50891	RAR/RXR	Metabolic Disease
ER 50891 is a *RARα* antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis .

HY-111844

*PROTAC RAR* Degrader-1**	PROTACs SNIPERs RAR/RXR	Neurological Disease Metabolic Disease Cancer
PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors (IAPs) ligands. IAPs-based degraders are also known as SNIPERs. PROTAC RAR Degrader-1 reduces *RARα* levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 (HY-13259). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 (HY-111843); Black: Linker (HY-140189); Blue: IAPs Ligand (HY-B0134)) .

HY-100273

AGN 194078	RAR/RXR Autophagy	Cancer
AGN 194078 is a selective *RARα* agonist with a K_d and EC₅₀ of 3 and 112 nM, respectively.

HY-105689

AGN 192870	RAR/RXR	Others
AGN 192870 is a *RAR* neutral antagonist with K_ds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC₅₀s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism . AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10475G

AM580 CD336; NSC608001; Ro 40-6055	RAR/RXR	Cancer
AM580 (CD336) (GMP) is AM580= (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

HY-B0091A

Adapalene sodium salt 5 Publications Verification CD 271 sodium salt	RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent *RAR* agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, *RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity of GOT1* in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity .

HY-108531A

ER 50891 quarterhydrate	RAR/RXR	Cancer
ER 50891 quarterhydrate is a *RARα* antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis .

HY-107218

11-Hydroxysugiol	RAR/RXR VD/VDR	Infection
11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating *RARα* and vitamin D₃ receptor (VDR) .

HY-14652R

Tamibarotene (Standard) Am 80 (Standard)	RAR/RXR Autophagy Apoptosis Reference Standards	Cancer
Tamibarotene (Standard) is the analytical standard of Tamibarotene. This product is intended for research and analytical applications. Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RARγ.

HY-118761

5,6-Epoxyretinoic acid 5,6-epoxy atRA; 5,6-epoxy RA	RAR/RXR	Metabolic Disease
all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC₅₀s=77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). 5,6-epoxy RA (1 μM) also induces growth arrest of MCF-7 and NB4 cells in vitro. It is a natural metabolite of all-trans retinoic acid, which is a metabolite of vitamin A.

HY-U00449A

AGN 193109 sodium	RAR/RXR	Cancer
AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for retinoic acid receptor (RAR), with K_d of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity .

HY-118420

BMS-185411	RAR/RXR	Cancer
BMS-185411 is a selective retinoic acid receptor alpha (RARα) antagonist, with an IC₅₀ value of 140 nM .

HY-10475R

AM580 (Standard) CD336 (Standard); NSC608001 (Standard); Ro 40-6055 (Standard)	Reference Standards RAR/RXR Autophagy	Cancer
AM580 (Standard) is the analytical standard of AM580. This product is intended for research and analytical applications. AM580 is a selective RARα agonist with IC50 and EC50 of 8 nM and 0.36 nM, respectively.

HY-U00449S

AGN 193109-d7	Isotope-Labeled Compounds RAR/RXR	Cancer
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-162827

RAR/RXR agonist-1	RAR/RXR Apoptosis	Cancer
RAR/RXR agonist-1 (compound 7) is a chlorinated retinoic acid isomer, a selective *RARα* agonist and a partial RXRα agonist. RAR/RXR agonist-1 can activate RXRα and induce G2/M arrest and apoptosis in cancer cells .

HY-100256R

Trifarotene (Standard) CD5789 (Standard)	Reference Standards RAR/RXR Autophagy	Inflammation/Immunology
Trifarotene (Standard) is the analytical standard of Trifarotene. This product is intended for research and analytical applications. Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ∼65-fold and ∼16-fold selectivitiy for the RARγ (EC₅₀=7.7 nM) over *RARα* (EC₅₀=500 nM) and RARβ (EC₅₀=125 nM), respectively .

HY-U00449R

AGN 193109 (Standard)	Reference Standards RAR/RXR	Cancer
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-B0091S

Adapalene-d3	Isotope-Labeled Compounds RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene-d₃ is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-B0091R

Adapalene (Standard) CD271 (Standard)	Reference Standards RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene (Standard) is the analytical standard of Adapalene. This product is intended for research and analytical applications. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent *RAR* agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, *RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1* in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-107397R

Ch55 (Standard)	Reference Standards RAR/RXR	Cancer
Ch55 (Standard) is the analytical standard of Ch55 (HY-107397). This product is intended for research and analytical applications. Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC₅₀ of 200 nM. Ch55 can be used for cancer research .

HY-180323

ER-38925	RAR/RXR	Inflammation/Immunology
ER-38925 is a retinoid agonist with selevtivity to retinoic acid receptor subtype α (RAR-α). ER-38925 prolongs the lifespan of the recipient mice dose-dependently. ER-38925 potently inhibits alloantigenstimulated donor T lymphocyte prolifertion in vitro. ER-38925 can prevent the development of antiallogeneic cytotoxic T lymphocyte response in mice. ER-38925 inhibits serum anti-DNA autoantibody production in mouse model of human chronic GVHD .

HY-100273R

AGN 194078 (Standard)	RAR/RXR Reference Standards Autophagy	Cancer
AGN 194078 (Standard) is the analytical standard of AGN 194078 (HY-100273). This product is intended for research and analytical applications. AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

HY-107395R

BMS 753 (Standard)	Reference Standards RAR/RXR	Inflammation/Immunology
BMS 753 (Standard) is the analytical standard of BMS 753 (HY-107395). This product is intended for research and analytical applications. BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a K_i of 2 nM .

HY-101106R

AR7 (Standard)	RAR/RXR Reference Standards	Neurological Disease Cancer
AR7 (Standard) is the analytical standard of AR7 (HY-101106). This product is intended for research and analytical applications. AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy .

HY-108530R

MM11253 (Standard)	Reference Standards RAR/RXR	Cancer
MM11253 (Standard) is the analytical standard of MM11253 (HY-108530). This product is intended for research and analytical applications. MM11253 is a potent and selective RARγ antagonist with an IC₅₀ of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists .

HY-W752012

Adapalene-13C6 CD271-¹³C₆	Isotope-Labeled Compounds RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene- ¹³C₆ (CD271- ¹³C₆) is the ¹³C-labeled Adapalene (HY-B0091). Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-105689R

AGN 192870 (Standard)	Reference Standards RAR/RXR	Others
AGN 192870 (Standard) is the analytical standard of AGN 192870 (HY-105689). This product is intended for research and analytical applications. AGN 192870 is a RAR neutral antagonist with Kds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC₅₀s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism . AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-183139

CD666	RAR/RXR AP-1	Cancer
CD666 is a selective retinoic acid receptor-γ (RAR-γ) agonist with a K_d of 68 nM. CD666 inhibits proliferation of cancer cells and shows synergistical effects and anti-AP-1 activity with IFN-γ. CD666 can be used for the research of breast cancer .

製品番号	製品名	構造式

HY-U00449S

AGN 193109-d7
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-B0091S

Adapalene-d3
Adapalene-d₃ is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-W752012

Adapalene-13C6

Adapalene- ¹³C₆ (CD271- ¹³C₆) is the ¹³C-labeled Adapalene (HY-B0091). Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .

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