2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. AM580

AM580 (CD336) (GMP) is AM580= (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist.

For research use only. We do not sell to patients.

AM580

AM580 Chemical Structure

CAS No. : 102121-60-8

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AM580 Related Antibodies

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Description

AM580 (CD336) (GMP) is AM580= (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
COS-7 EC50
0.3 nM
Compound: AM-580
Activity at human RARalpha ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
Activity at human RARalpha ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
[PMID: 19058965]
COS-7 EC50
13 nM
Compound: AM-580
Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
Activity at human RARgamma ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
[PMID: 19058965]
COS-7 EC50
8.6 nM
Compound: AM-580
Activity at human RARbeta ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
Activity at human RARbeta ligand binding domain expressed in COS7 cells co-transfected with Gal4-DBD assessed as transcriptional activation after 16 hrs by Gal4 response element-driven luciferase reporter gene assay
[PMID: 19058965]
HL-60 ED50
3.4 x 10-10 M
Compound: 5
Compound was tested for differentiation-inducing activity against human promyelocytic leukemia cell line HL-60
Compound was tested for differentiation-inducing activity against human promyelocytic leukemia cell line HL-60
[PMID: 2795600]
Panel leukemia (Carcinoma cell lines) ED50
3.4 x 10-10 M
Compound: AM-580
Effective dose for differentiation -inducing activity against human promyelocytic leukemia cells
Effective dose for differentiation -inducing activity against human promyelocytic leukemia cells
[PMID: 3184125]
In Vitro

AM580 (GMP) (0.05 μM) induces mouse embryonic fibroblasts (MEFs) convert into chemically induced pluripotent stem cells (CiPSCs) with the adding in stage I and stage II medium[1].
AM580 (GMP) (0-10 μM; 4 d) induces SH-SY5Y cells develop into neuron-like cells[2].
AM580 (GMP) shows powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells[3].
AM580 (GMP) (2.5 μM; 4 d) induces myeloid progenitors develop into neutrophils[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AM580 Related Antibodies
Molecular Weight

351.44

Formula

C22H25NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(CC1)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C1(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AM580 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM580 (GMP)102121-60-8CD336 (GMP)NSC608001 (GMP)Ro 40-6055 (GMP)RAR/RXRRetinoic acid receptorsRetinoid X receptorsGMPcell therapy manufactureMEFCiPSCSH-SY5Yneuronpromyelocytic leukemiamyeloid progenitorneutrophilInhibitorinhibitorinhibit

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HY-10475G
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