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AGN 193109 sodium

10 Cited Publications
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Based on 10 publication(s) in Google Scholar

AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for retinoic acid receptor (RAR), with Kd of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

For research use only. We do not sell to patients.

  • CAS No.: 2319838-82-7
  • Formula: C28H23NaO2
  • Molecular Weight:414.47
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • AGN 193109 sodium Chemical Structure
    AGN 193109 sodium Chemical Structure
  • Experimental Validation Results for AGN 193109 sodium
  • Experimental Validation Results for AGN 193109 sodium
  • Experimental Validation Results for AGN 193109 sodium
CAS No.: 2319838-82-7
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In Vivo ImagingCell Proliferation/Viability AssayFlow Cytometry
  • Cell Proliferation/Viability Assay
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  • AGN 193109 sodium Chemical Structure
    AGN 193109 sodium Chemical Structure
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    AGN 193109 sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Nov:77:103361. [Abstract]

    Customer Validation
     Relative viability shows retinoic acid receptor α (RARA) resisted KRAS G12C mutant cells to ferroptosis caused by RSL3, IKE, Sotorasib and Adagtasib (IC50), demonstrated by medications with RARA inhibitor AGN193109 (1000 nM; 72 h) for 72 h.

  • 1/16

    AGN 193109 sodium purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2023 Nov 17.

    Customer Validation
     BMDCs (5-7 days) cultured from RA reporter mice are exposed to SiO2 (100 μg/mL) and AM80 (20 μM) solely for 14 h, BMDCs are pretreated with AGN193109 (1 μM; 60 min) for 60 min, and then exposed to SiO2 (100 μg/mL) for 14 h and incubated with DDAOG (10 μM). DDAO fluorescence is analyzed by flow cytometry. Data are representative of three independent experiments.

  • 1/16

    AGN 193109 sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2020 Nov 4;6(45):eaaz1410. [Abstract]

    Customer Validation
     AGN 193109 (2 or 4 mg/kg; i.p.; every day, from 2 to 12 dpf). Reconstruction of μCT data reflects hard bony callus formation and Safranin O staining that shows cartilage formation of Lsd1Prx1 and control mice treated with AGN193109.

  • AGN 193109 sodium