2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. AGN 193109 sodium

AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for retinoic acid receptor (RAR), with Kd of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

For research use only. We do not sell to patients.

CAS No. : 2319838-82-7

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AGN 193109 sodium Related Antibodies

Top Publications Citing Use of Products

    AGN 193109 sodium purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Nov:77:103361.

    Relative viability shows retinoic acid receptor α (RARA) resisted KRAS G12C mutant cells to ferroptosis caused by RSL3, IKE, Sotorasib and Adagtasib (IC50), demonstrated by medications with RARA inhibitor AGN193109 (1000 nM; 72 h) for 72 h.

    AGN 193109 sodium purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2023 Nov 17.

    BMDCs (5-7 days) cultured from RA reporter mice are exposed to SiO2 (100 μg/mL) and AM80 (20 μM) solely for 14 h, BMDCs are pretreated with AGN193109 (1 μM; 60 min) for 60 min, and then exposed to SiO2 (100 μg/mL) for 14 h and incubated with DDAOG (10 μM). DDAO fluorescence is analyzed by flow cytometry. Data are representative of three independent experiments.

    AGN 193109 sodium purchased from MedChemExpress. Usage Cited in: Sci Adv. 2020 Nov 4;6(45):eaaz1410.  [Abstract]

    AGN 193109 (2 or 4 mg/kg; i.p.; every day, from 2 to 12 dpf). Reconstruction of μCT data reflects hard bony callus formation and Safranin O staining that shows cartilage formation of Lsd1Prx1 and control mice treated with AGN193109.

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    Description

    AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for retinoic acid receptor (RAR), with Kd of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity[1][2].

    IC50 & Target

    RXR α

    2 nM (Kd)

    RXR β

    2 nM (Kd)

    RXR γ

    2 nM (Kd)

    Molecular Weight

    414.47

    Formula

    C28H23NaO2
    CAS No.
    SMILES

    O=C(O[Na])C1=CC=C(C#CC2=CC=C3C(C)(C)CC=C(C4=CC=C(C)C=C4)C3=C2)C=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    AGN 193109 sodium Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AGN 1931092319838-82-7AGN193109AGN-193109RAR/RXRRetinoic acid receptorsRetinoid X receptorsECE16-1Inhibitorinhibitorinhibit

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