1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. AGN 194078

AGN 194078 

Cat. No.: HY-100273
Handling Instructions

AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

For research use only. We do not sell to patients.

AGN 194078 Chemical Structure

AGN 194078 Chemical Structure

CAS No. : 321995-62-4

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

IC50 & Target


112 nM (EC50)


3 nM (Kd)

In Vitro

AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a Kd value of 3 nM, while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activated RARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name



Applicant Name *


Email address *

Phone number *


Organization name *

Department *


Requested quantity *

Country or Region *



Bulk Inquiry

Inquiry Information

Product Name:
AGN 194078
Cat. No.:
MCE Japan Authorized Agent: