1. Metabolic Enzyme/Protease
    Autophagy
  2. RAR/RXR
    Autophagy
  3. AGN 194078

AGN 194078 

Cat. No.: HY-100273
Handling Instructions

AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

For research use only. We do not sell to patients.

AGN 194078 Chemical Structure

AGN 194078 Chemical Structure

CAS No. : 321995-62-4

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Description

AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

IC50 & Target

RARα

112 nM (EC50)

RARα

3 nM (Kd)

In Vitro

AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a Kd value of 3 nM, while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activated RARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested[1].

Molecular Weight

403.42

Formula

C₂₂H₂₃F₂NO₄

CAS No.

321995-62-4

SMILES

O=C(O)C1=C(F)C=C(NC(C2=C(O)C=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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AGN 194078
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