1. Metabolic Enzyme/Protease
  2. RAR/RXR

AGN 194078 

Cat. No.: HY-100273
Handling Instructions

AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

For research use only. We do not sell to patients.

AGN 194078 Chemical Structure

AGN 194078 Chemical Structure

CAS No. : 321995-62-4

Size Price Stock
1 mg USD 1127 Get quote
5 mg USD 1803 Get quote
10 mg USD 2885 Get quote

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

IC50 & Target[1]

RARα

112 nM (EC50)

RARα

3 nM (Kd)

In Vitro

AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a Kd value of 3 nM, while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activated RARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4788 mL 12.3940 mL 24.7881 mL
5 mM 0.4958 mL 2.4788 mL 4.9576 mL
10 mM 0.2479 mL 1.2394 mL 2.4788 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

403.42

Formula

C₂₂H₂₃F₂NO₄

CAS No.

321995-62-4

SMILES

O=C(O)C1=C(F)C=C(NC(C2=C(O)C=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AGN 194078
Cat. No.:
HY-100273
Quantity:

AGN 194078

Cat. No.: HY-100273