2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Autophagy
  3. RAR/RXR Autophagy
  4. AGN 194078

AGN 194078 

Cat. No.: HY-100273 Purity: 98.00%
COA Handling Instructions

AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

For research use only. We do not sell to patients.

AGN 194078 Chemical Structure

AGN 194078 Chemical Structure

CAS No. : 321995-62-4

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 528 In-stock
Solution
10 mM * 1 mL in DMSO USD 528 In-stock
Solid
1 mg USD 228 In-stock
5 mg USD 480 In-stock
10 mg USD 750 In-stock
25 mg USD 1500 In-stock
50 mg USD 2450 In-stock
100 mg USD 3900 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

AGN 194078 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.

IC50 & Target

Kd: 4 nM (RARα)[1]
EC50: 140 nM (RARα)[1]
In Vitro

AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a Kd value of 3 nM, while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activated RARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AGN 194078 Related Antibodies
Molecular Weight

403.42

Appearance

Solid

Formula

C22H23F2NO4
CAS No.
SMILES

O=C(O)C1=C(F)C=C(NC(C2=C(O)C=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (247.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4788 mL 12.3940 mL 24.7881 mL
5 mM 0.4958 mL 2.4788 mL 4.9576 mL
10 mM 0.2479 mL 1.2394 mL 2.4788 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.20 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.20 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.20 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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AGN 194078 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AGN 194078321995-62-4AGN194078AGN-194078RAR/RXRAutophagyRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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