2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Autophagy Apoptosis
  3. RAR/RXR Autophagy Apoptosis
  4. Adapalene sodium salt

Adapalene sodium salt  (Synonyms: CD 271 sodium salt)

Cat. No.: HY-B0091A Purity: 99.69%
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Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity.

For research use only. We do not sell to patients.

CAS No. : 911110-93-5

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Based on 5 publication(s) in Google Scholar

Other Forms of Adapalene sodium salt:

Adapalene sodium salt Related Antibodies

Top Publications Citing Use of Products

    Adapalene sodium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 27:e09340.  [Abstract]

    Flow cytometry analysis showing HLA‐DR expression after IFN‐γ +AM580, IFN‐γ +Adapalene, and IFN‐γ +Palovarotene treatment for 48 h.

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    Description

    Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity[1][2][3].

    IC50 & Target

    AC50: 2.3 nM (RARβ), 9.3 nM (RARγ), and 22 nM (RARα)[1]
    In Vitro

    Adapalene sodium salt (1-200 μM; 24 h) inhibits the viability of ES-2, HOV-7, MCF-7 , Hela, SW1990, HT1080, and MM-468 cells, with IC50s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively[2].
    Adapalene sodium salt (10-40 μM; 24 h) induces ES-2 cells apoptosis and inhibits proliferation in vitro[2].
    Adapalene sodium salt (3-30 μM; 6-24 h) significantly increases the G1-phase population in LoVo or DLD1 cells[3].
    Adapalene sodium salt (1-200 μM) inhibits GOT1 activity, with an IC50 of 21.79 μM[2].
    Adapalene sodium salt (10-6-10-3 nM) inhibits the expression of plasma membrane-associated enzyme transglutaminase Type I, with an IC50 of 2.5 nM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Adapalene sodium salt Related Antibodies

    Cell Viability Assay[2]

    Cell Line: Pancreatic cancer (SW1990, Aspc-1), breast cancer (mm-231, mm-468, MCF-7), liver cancer (Hep3B), cervical cancer (Hela), ovarian cancer (HOV-7, ES-2), normal cells (CHO, L929)
    Concentration: 1-200 μM
    Incubation Time: 24 hours
    Result: Inhibited the viability of cancer cells with higher GOT1 protein expression.

    Apoptosis Analysis[2]

    Cell Line: ES-2 cells
    Concentration: 10, 20, 40 μM
    Incubation Time: 24 hours
    Result: Showed a significant increase in apoptosis compared with the control group.
    Down regulated the expression of anti-apoptotic protein Bcl-2 and PARP.

    Cell Cycle Analysis[3]

    Cell Line: LoVo or DLD1 cells
    Concentration: 3, 10, 30 μM
    Incubation Time: 6, 12, 24 hours
    Result: Caused cell cycle arrest in G1 phase in a dose- and time-dependent manner.
    In Vivo

    Adapalene sodium salt (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female BALB/C nude mice (15 g, 4-5 weeks) were injected with DLD1 cells[3]
    Dosage: 15, 20, 65, 100 mg/kg
    Administration: P.o. daily for 21 days
    Result: Significantly reduced tumor weight and volume.
    Clinical Trial
    Molecular Weight

    434.50

    Formula

    C28H27NaO3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(C1=CC2=CC=C(C3=CC=C(OC)C(C45C[C@@H](C[C@H](C6)C5)C[C@@H]6C4)=C3)C=C2C=C1)[O-].[Na+]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 4.17 mg/mL (9.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3015 mL 11.5075 mL 23.0150 mL
    5 mM 0.4603 mL 2.3015 mL 4.6030 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.3015 mL 11.5075 mL 23.0150 mL 57.5374 mL
    5 mM 0.4603 mL 2.3015 mL 4.6030 mL 11.5075 mL
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    Adapalene sodium salt Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Adapalene911110-93-5CD 271CD271CD-271RAR/RXRAutophagyApoptosisRetinoic acid receptorsRetinoid X receptorsretinoidacneRARRARβRARγRARαGOT1tumorInhibitorinhibitorinhibit

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