2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. MM11253

MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists.

For research use only. We do not sell to patients.

MM11253 Chemical Structure

MM11253 Chemical Structure

CAS No. : 345952-44-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO USD 102 In-stock
Solid
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10 mg USD 160 In-stock
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50 mg USD 550 In-stock
100 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

MM11253 Related Antibodies

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Description

MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists[1][3].

In Vitro

MM11253 blocks the ability of MM11254 and MM11389 to inhibit squamous cell carcinoma cell growth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MM11253 Related Antibodies
Molecular Weight

462.67

Formula

C28H30O2S2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C2C=C(C3(C4=CC=C5C(C)(C)CCC(C)(C)C5=C4)SCCS3)C=CC2=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (270.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1614 mL 10.8068 mL 21.6137 mL
5 mM 0.4323 mL 2.1614 mL 4.3227 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1614 mL 10.8068 mL 21.6137 mL 54.0342 mL
5 mM 0.4323 mL 2.1614 mL 4.3227 mL 10.8068 mL
10 mM 0.2161 mL 1.0807 mL 2.1614 mL 5.4034 mL
15 mM 0.1441 mL 0.7205 mL 1.4409 mL 3.6023 mL
20 mM 0.1081 mL 0.5403 mL 1.0807 mL 2.7017 mL
25 mM 0.0865 mL 0.4323 mL 0.8645 mL 2.1614 mL
30 mM 0.0720 mL 0.3602 mL 0.7205 mL 1.8011 mL
40 mM 0.0540 mL 0.2702 mL 0.5403 mL 1.3509 mL
50 mM 0.0432 mL 0.2161 mL 0.4323 mL 1.0807 mL
60 mM 0.0360 mL 0.1801 mL 0.3602 mL 0.9006 mL
80 mM 0.0270 mL 0.1351 mL 0.2702 mL 0.6754 mL
100 mM 0.0216 mL 0.1081 mL 0.2161 mL 0.5403 mL
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MM11253 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM11253345952-44-5MM 11253MM-11253RAR/RXRRetinoic acid receptorsRetinoid X receptorsSelective RARγ antagonistInhibitorinhibitorinhibit

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