1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. MM11253

MM11253 

Cat. No.: HY-108530
Handling Instructions

MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists.

For research use only. We do not sell to patients.

MM11253 Chemical Structure

MM11253 Chemical Structure

CAS No. : 345952-44-5

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Description

MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists[1][3].

IC50 & Target[1]

RARγ

44 nM (IC50)

RARα

1000 nM (IC50)

RARβ

>1000 nM (IC50)

RXRα

>1000 nM (IC50)

In Vitro

MM11253 blocks the ability of MM11254 and MM11389 to inhibit squamous cell carcinoma cell growth[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

462.67

Formula

C28H30O2S2

CAS No.
SMILES

O=C(C1=CC=C2C=C(C3(C4=CC=C5C(C)(C)CCC(C)(C)C5=C4)SCCS3)C=CC2=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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MM11253
Cat. No.:
HY-108530
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