1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. Ch55

Ch55 

Cat. No.: HY-107397 Purity: 99.86%
Handling Instructions

Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research.

For research use only. We do not sell to patients.

Ch55 Chemical Structure

Ch55 Chemical Structure

CAS No. : 110368-33-7

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5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 425 In-stock
Estimated Time of Arrival: December 31
25 mg USD 850 Get quote
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Based on 1 publication(s) in Google Scholar

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Description

Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2].

IC50 & Target[1]

RARα

 

RARβ

 

In Vitro

Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM)[1].

Molecular Weight

364.48

Formula

C₂₄H₂₈O₃

CAS No.

110368-33-7

SMILES

O=C(O)C1=CC=C(/C=C/C(C2=CC(C(C)(C)C)=CC(C(C)(C)C)=C2)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: 99.86%

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Keywords:

Ch55Ch 55Ch-55RAR/RXRRetinoic acid receptorsRetinoid X receptorsRAR-αRAR-βretinoiddifferentiationanti-cancertransglutaminaseInhibitorinhibitorinhibit

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Ch55
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HY-107397
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