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RNA+polymerase+inhibitor

" in MedChemExpress (MCE) Product Catalog:

35

Inhibitors & Agonists

2

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7

Natural
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6

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14768
    Favipiravir
    Maximum Cited Publications
    50 Publications Verification

    T-705

    		 DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial Infection
    Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
    Favipiravir
  • HY-N0112
    Dihydromyricetin
    Maximum Cited Publications
    23 Publications Verification

    Ampelopsin; Ampeloptin

    		 mTOR Influenza Virus DNA/RNA Synthesis Autophagy Infection Cancer
    Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM.
    Dihydromyricetin
  • HY-103586
    GS-441524
    25+ Cited Publications

    		 DNA/RNA Synthesis SARS-CoV Infection
    GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .
    GS-441524
  • HY-N0540
    Cynaroside
    10+ Cited Publications

    Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside

    		 Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal Infection Cardiovascular Disease Cancer
    Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .
    Cynaroside
  • HY-D1020
    7-Aminoactinomycin D
    5+ Cited Publications

    7-AAD

    		 DNA/RNA Synthesis Bacterial DNA Stain Antibiotic Infection Cancer
    7-Aminoactinomycin D (7-AAD) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .
    7-Aminoactinomycin D
  • HY-17580
    Fidaxomicin
    5+ Cited Publications

    OPT-80; PAR-101

    		 DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Infection
    Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .
    Fidaxomicin
  • HY-16662
    Oncrasin-1

    		DNA/RNA Synthesis Ras Apoptosis Cancer
    Oncrasin-1 is an RNA polymerase inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCι and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer .
    Oncrasin-1
  • HY-17580S
    Fidaxomicin-d7

    		Isotope-Labeled Compounds DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Infection
    Fidaxomicin-d7 (OPT-80-D7) is the deuterium labeled Fidaxomicin. Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora .
    Fidaxomicin-d7
  • HY-128917
    DNA31

    		DNA/RNA Synthesis Infection
    DNA31 is a potent RNA polymerase inhibitor .
    DNA31
  • HY-148478
    MMV688845

    (R)-GSK1729177A

    		 DNA/RNA Synthesis Infection
    MMV688845 is a nontuberculous mycobacteria (NTM) RNA polymerase inhibitor with bactericidal activity against Mycobacterium abscessus and anti-tuberculosis efficacy .
    MMV688845
  • HY-103586A
    GS-441524 hydrochloride
    25+ Cited Publications

    		 DNA/RNA Synthesis SARS-CoV Infection
    GS-441524 hydrochloride is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 hydrochloride competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 hydrochloride inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 hydrochloride reduces viral RNA levels in cats. GS-441524 hydrochloride can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .
    GS-441524 hydrochloride
  • HY-128897
    MC-VC-PABC-DNA31

    		Drug-Linker Conjugates for ADC Cancer
    MC-VC-PABC-DNA31 is a agent-linker conjugate for ADC with potent antitumor activity by using DNA31 (a potent RNA polymerase inhibitor), linked via the ADC linker MC-VC-PABC.
    MC-VC-PABC-DNA31
  • HY-N0540R
    Cynaroside (Standard)
    10+ Cited Publications

    Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)

    		 Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal Reference Standards Infection Cancer
    Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .
    Cynaroside (Standard)
  • HY-128909
    MC-Val-Cit-PAB-rifabutin

    		Drug-Linker Conjugates for ADC Cancer
    MC-Val-Cit-PAB-rifabutin is a agent-linker conjugate for ADC with potent antitumor activity by using rifabutin (an DNA-dependent RNA polymerase inhibitor), linked via the ADC linker MC-Val-Cit-PAB.
    MC-Val-Cit-PAB-rifabutin
  • HY-148167
    2'-Deoxy-2'-fluoro-l-uridine

    		DNA/RNA Synthesis Virus Protease Infection
    2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral RNA polymerase inhibitor, thereby inhibiting RNA virus replication .
    2'-Deoxy-2'-fluoro-l-uridine
  • HY-126406
    Tirandamycin A

    		Bacterial DNA/RNA Synthesis Parasite Antibiotic Infection
    Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties .
    Tirandamycin A
  • HY-163015
    RNA polymerase-IN-1

    		DNA/RNA Synthesis Infection
    RNA polymerase-IN-1 (compound 4) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .
    RNA polymerase-IN-1
  • HY-14768R
    Favipiravir (Standard)

    T-705 (Standard)

    		 Reference Standards DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial Infection
    Favipiravir (Standard) is the analytical standard of Favipiravir. This product is intended for research and analytical applications. Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
    Favipiravir (Standard)
  • HY-N0112R
    Dihydromyricetin (Standard)

    Ampelopsin (Standard); Ampeloptin (Standard)

    		 Reference Standards mTOR Influenza Virus DNA/RNA Synthesis Autophagy Infection Cancer
    Dihydromyricetin (Standard) is the analytical standard of Dihydromyricetin. This product is intended for research and analytical applications. Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM.
    Dihydromyricetin (Standard)
  • HY-153696
    MRL-436

    		DNA/RNA Synthesis Bacterial Infection
    MRL-436 is a RNA polymerase inhibitor with antibacterial activity. MRL-436 exerts its antibacterial activity dependent on residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. MRL-436 inhibits Rifampicin (HY-B0272)-resistant RNA polymerase derivatives and exhibits antibacterial activity against Rifampicin-resistant strains .
    MRL-436
  • HY-17580R
    Fidaxomicin (Standard)

    OPT-80 (Standard); PAR-101 (Standard)

    		 Reference Standards DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Infection
    Fidaxomicin (Standard) is the analytical standard of Fidaxomicin. This product is intended for research and analytical applications. Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .
    Fidaxomicin (Standard)
  • HY-14768S
    Favipiravir-13C15N

    T-705-13C15N

    		 Isotope-Labeled Compounds Bacterial DNA/RNA Synthesis SARS-CoV Influenza Virus Infection
    Favipiravir- 13C 15N (T-705- 13C 15N) is 13C and 15N labeled Favipiravir. Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
    Favipiravir-13C15N
  • HY-163016
    RNA polymerase-IN-2

    		DNA/RNA Synthesis Infection
    RNA polymerase-IN-2 (compound 5) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-2 inhibits CYP isozymes .
    RNA polymerase-IN-2
  • HY-119161
    VX-759

    VCH-759

    		 DNA/RNA Synthesis HCV HCV Protease Infection
    VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C .
    VX-759
  • HY-179029
    RNA polymerase-IN-4

    		DNA/RNA Synthesis Influenza Virus Infection
    RNA polymerase-IN-4 is a RNA polymerase inhibitor with an EC50 of 22.81 nM. RNA polymerase-IN-4 exhibits potent anti-influenza virus activity (EC50 = 3.76 nM), relatively low cytotoxicity (CC50 = 29.91 μM). RNA polymerase-IN-4 can be used for the research of infection, such as influenza virus infection .
    RNA polymerase-IN-4
  • HY-W769714
    Favipiravir-13C3

    T-705-13C3

    		 Isotope-Labeled Compounds DNA/RNA Synthesis Influenza Virus Infection
    Favipiravir- 13C3 is the 13C labeled isotope of Favipiravir (HY-14768). Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM.
    Favipiravir-13C3
  • HY-N0112S
    Dihydromyricetin-d4

    Ampelopsin-d4; Ampeloptin-d4

    		 Isotope-Labeled Compounds Autophagy Influenza Virus mTOR DNA/RNA Synthesis Infection Cancer
    Dihydromyricetin-d4 (Ampelopsin-d4) is deuterium labeled Dihydromyricetin. Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM.
    Dihydromyricetin-d4
  • HY-DY1099
    7-Aminoactinomycin D (solution)

    7-AAD (solution)

    		 DNA/RNA Synthesis DNA Stain Bacterial Antibiotic Cancer
    7-Aminoactinomycin D (solution) (7-AAD (solution)) a cell-impermeant fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .
    Solvent and concentration: DMSO: 1 mg/mL
    7-Aminoactinomycin D (solution)
  • HY-124184
    D715-2441

    		DNA/RNA Synthesis Influenza Virus Infection
    D715-2441 is an influenza virus RNA polymerase inhibitor (IC50=1.7-4.4 μM). D715-2441 exhibits broad-spectrum antiviral activity against multiple influenza A strains. D715-2441 is promising for research of seasonal influenza and influenza viruses .
    D715-2441
  • HY-128306
    HCV-IN-50

    		HCV Protease DNA/RNA Synthesis Infection
    HCV-IN-50 (Compound 2) is a competitive and selective HCV NS5B RNA-dependent RNA polymerase inhibitor with an IC50 of 0.3  μM for NS5B △C21 enzyme over △C55 enzyme. HCV-IN-50 has an antiviral activity and efficiently blocks replication of HCV subgenomic replicons especially mutant replicons .
    HCV-IN-50
  • HY-17580S1
    Fidaxomicin-d6

    OPT-80-d6; PAR-101-d6

    		 Isotope-Labeled Compounds Antibiotic Apoptosis DNA/RNA Synthesis Bacterial Infection
    Fidaxomicin-d6 (OPT-80-d6) is the deuterium labeled Fidaxomicin (HY-17580). Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .
    Fidaxomicin-d6
  • HY-174162A
    2'-O-Methylguanosine-5'-O-triphosphate sodium

    2'-Methyl GTP sodium

    		 Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Infection
    2'-O-Methylguanosine-5'-O-triphosphate sodium (2'-Methyl GTP sodium), a methylated derivative of Guanosine 5'-triphosphate (HY-W010737), is a HCV NS5B RNA-dependent RNA polymerase inhibitor. 2'-O-Methylguanosine-5'-O-triphosphate sodium is a nucleotide competitor of GTP and acts as a chain terminator to inhibit RNA synthesis. 2'-O-Methylguanosine-5'-O-triphosphate sodium can be used for HCV infections research .
    2'-O-Methylguanosine-5'-O-triphosphate sodium
  • HY-12983B
    ALS-8112-TP

    		Drug Metabolite DNA/RNA Synthesis Infection
    ALS-8112-TP is the 5'-triphosphate metabolite of ALS-8112 (HY-12983). ALS-8112-TP is a potent, selective and competitive respiratory syncytial virus (RSV) RNA polymerase inhibitor, with selectivity against polymerases from host or viruses unrelated to RSV such as hepatitis C virus (HCV). ALS-8112-TP can be efficiently recognized by the recombinant RSV polymerase complex, causing chain termination of RNA synthesis. ALS-8112-TP can be used for RSV-infection research .
    ALS-8112-TP
  • HY-103586R
    GS-441524 (Standard)

    		Reference Standards DNA/RNA Synthesis SARS-CoV Infection
    GS-441524 (Standard) is the analytical standard of GS-441524 (HY-103586). GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .
    GS-441524 (Standard)
  • HY-103586S2
    GS-441524-d

    		Isotope-Labeled Compounds DNA/RNA Synthesis SARS-CoV Infection
    GS-441524-d is the deuterium labeled GS-441524 (HY-103586). GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .
    GS-441524-d

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