1. Anti-infection
    Apoptosis
  2. Bacterial
    Apoptosis
    Antibiotic
  3. Fidaxomicin

Fidaxomicin (Synonyms: OPT-80; PAR-101)

Cat. No.: HY-17580 Purity: 99.85%
Handling Instructions

Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.

For research use only. We do not sell to patients.

Fidaxomicin Chemical Structure

Fidaxomicin Chemical Structure

CAS No. : 873857-62-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 76 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 76 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 65 In-stock
Estimated Time of Arrival: December 31
50 mg USD 90 In-stock
Estimated Time of Arrival: December 31
100 mg USD 150 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Fidaxomicin:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Fidaxomicin

    Fidaxomicin purchased from MCE. Usage Cited in: BMC Med. 2020 Jul 31;18(1):204.

    Western blotting analysis of protein expression of ZIKV NS3 in the cell lysates of SNB19 for the anti-ZIKV activity of fidaxomicin at indicated hpi. Fidaxomicin blocks ZIKV infection in vitro.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora[1].

    Clinical Trial
    Molecular Weight

    1058.04

    Formula

    C52H74Cl2O18

    CAS No.
    SMILES

    O=C(C(C(O)=C(Cl)C(O)=C1Cl)=C1CC)O[[email protected]]([[email protected]](O[[email protected]]2OC/C(C(O[[email protected]](C/C=C3C)([H])[[email protected]](O)C)=O)=C\C=C\C[[email protected]@H](/C(C)=C\[[email protected]](CC)[[email protected]@H](O[[email protected]@](OC(C)(C)[[email protected]@H](OC(C(C)C)=O)[[email protected]@H]4O)([H])[[email protected]]4O)\C(C)=C/3)O)C)[[email protected]@H]([[email protected]@H]2OC)O

    Structure Classification
    Source

    Clostridium difficile

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 33 mg/mL (31.19 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.9451 mL 4.7257 mL 9.4514 mL
    5 mM 0.1890 mL 0.9451 mL 1.8903 mL
    10 mM 0.0945 mL 0.4726 mL 0.9451 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (2.36 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (2.36 mM); Clear solution

    *All of the co-solvents are available by MCE.
    References

    Purity: 99.85%

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    Product Name:
    Fidaxomicin
    Cat. No.:
    HY-17580
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