Fidaxomicin-d7
Based on 1 Customer Validation
Fidaxomicin-d7 (OPT-80-D7) is the deuterium labeled Fidaxomicin. Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 97.18%
- No. CAS: 2143934-06-7
- Fòrmula: C52H67D7Cl2O18
- Peso molecular:1065.08
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
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RNA Polymerase |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 2143934-06-7
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Unlabeled CAS 873857-62-6
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Appearance Solid
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Peso molecular 1065.08
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Fòrmula C52H67D7Cl2O18
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Color White to light yellow
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SMILES
C(O[C@H]1[C@H](O)[C@H](OC)[C@H](OC/C=2/C(=O)O[C@]([C@@H](C)O)(C/C=C(\C)/C=C(\C)/[C@H](O[C@H]3[C@@H](O)[C@@H](O)[C@H](OC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])=O)C(C)(C)O3)[C@@H](CC)/C=C(\C)/[C@@H](O)C/C=C/C2)[H])O[C@@H]1C)(=O)C4=C(CC)C(Cl)=C(O)C(Cl)=C4O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Poxton IR, et al. Fidaxomicin: a new macrocyclic, RNA polymerase-inhibiting antibiotic for the treatment of Clostridium difficile infections. Future Microbiol. 2010 Apr;5(4):539-48. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fidaxomicin-d7 Related Classifications
HY-17580S Related Classifications
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