2'-O-Methylguanosine-5'-O-triphosphate sodium  (Synonyms: 2'-Methyl GTP sodium)

2'-O-Methylguanosine-5'-O-triphosphate sodium (2'-Methyl GTP sodium), a methylated derivative of Guanosine 5'-triphosphate (HY-W010737), is a HCV NS5B RNA-dependent RNA polymerase inhibitor. 2'-O-Methylguanosine-5'-O-triphosphate sodium is a nucleotide competitor of GTP and acts as a chain terminator to inhibit RNA synthesis. 2'-O-Methylguanosine-5'-O-triphosphate sodium can be used for HCV infections research^[1].

625.13

C₁₁H₁₄N₅Na₄O₁₄P₃

O=C1NC(N)=NC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@@H](O)[C@H]3OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dutartre H, et al. A relaxed discrimination of 2'-O-methyl-GTP relative to GTP between de novo and Elongative RNA synthesis by the hepatitis C RNA-dependent RNA polymerase NS5B. J Biol Chem. 2005 Feb 25;280(8):6359-68.  [Content Brief]