1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. MC-Val-Cit-PAB-rifabutin

MC-Val-Cit-PAB-rifabutin is a agent-linker conjugate for ADC with potent antitumor activity by using rifabutin (an DNA-dependent RNA polymerase inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

For research use only. We do not sell to patients.

MC-Val-Cit-PAB-rifabutin Chemical Structure

MC-Val-Cit-PAB-rifabutin Chemical Structure

CAS No. : 2055900-34-8

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1 mg USD 320 In-stock
5 mg USD 900 In-stock
10 mg USD 1440 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

MC-Val-Cit-PAB-rifabutin is a agent-linker conjugate for ADC with potent antitumor activity by using rifabutin (an DNA-dependent RNA polymerase inhibitor), linked via the ADC linker MC-Val-Cit-PAB.

IC50 & Target

Traditional Cytotoxic Agents

 

Molecular Weight

1438.10

Formula

C74H101ClN10O17

CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

O=C1C2=C(C(C)=C(C3=C2C4=NC5(NC4=C(C3=O)N6)CC[N+](CC(C)C)(CC5)CC7=CC=C(C=C7)NC([C@@H](NC([C@@H](NC(CCCCCN8C(C=CC8=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)O)O[C@]1(C)O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@H]([C@H](/C=C/C=C(C)\C6=O)C)O.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (13.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6954 mL 3.4768 mL 6.9536 mL
5 mM 0.1391 mL 0.6954 mL 1.3907 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6954 mL 3.4768 mL 6.9536 mL 17.3840 mL
5 mM 0.1391 mL 0.6954 mL 1.3907 mL 3.4768 mL
10 mM 0.0695 mL 0.3477 mL 0.6954 mL 1.7384 mL
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MC-Val-Cit-PAB-rifabutin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MC-Val-Cit-PAB-rifabutin
Cat. No.:
HY-128909
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