1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. SPDB-DM4

SPDB-DM4 

Cat. No.: HY-12460 Purity: 97.36%
Handling Instructions

SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity.

For research use only. We do not sell to patients.

SPDB-DM4 Chemical Structure

SPDB-DM4 Chemical Structure

CAS No. : 1626359-62-3

Size Price Stock Quantity
1 mg USD 420 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity.

IC50 & Target

Maytansinoids

 

Molecular Weight

995.59

Formula

C₄₆H₆₃ClN₄O₁₄S₂

CAS No.
SMILES

C[[email protected]]1([[email protected]](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([[email protected]](C)N(C)C(CCC(C)(C)SSCCCC(ON(C4=O)C(CC4)=O)=O)=O)=O)[[email protected]]([[email protected]@H]([[email protected]](OC5=O)([H])C[[email protected]]([[email protected]](/C=C/C=C(C)/C2)([H])OC)(N5)O)C)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (50.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0044 mL 5.0221 mL 10.0443 mL
5 mM 0.2009 mL 1.0044 mL 2.0089 mL
10 mM 0.1004 mL 0.5022 mL 1.0044 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.51 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SPDB-DM4Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Product Name:
SPDB-DM4
Cat. No.:
HY-12460
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