2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Acetylene-linker-Val-Cit-PABC-MMAE

Acetylene-linker-Val-Cit-PABC-MMAE  (Synonyms: LCB14-0602)

Cat. No.: HY-19812 Purity: 95.08
COA Handling Instructions

Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE). Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a agent-linker conjugate for ADC.

For research use only. We do not sell to patients.

Acetylene-linker-Val-Cit-PABC-MMAE Chemical Structure

Acetylene-linker-Val-Cit-PABC-MMAE Chemical Structure

CAS No. : 1411977-95-1

Size Price Stock Quantity
1 mg USD 420 In-stock
5 mg USD 1020 In-stock
10 mg USD 1620 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE). Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a agent-linker conjugate for ADC.

IC50 & Target

Auristatin

 

Molecular Weight

1307.62

Appearance

Solid

Formula

C67H106N10O16
CAS No.
SMILES

O=C([[email protected]](CCCNC(N)=O)NC([[email protected]](C(C)C)NC(COCCOCCOCC#C)=O)=O)NC1=CC=C(COC(N(C)[[email protected]@H](C(C)C)C(N[[email protected]@H](C(C)C)C(N([[email protected]]([[email protected]@H](CC(N2[[email protected]]([[email protected]](OC)[[email protected]](C(N[[email protected]@H]([[email protected]@H](O)C3=CC=CC=C3)C)=O)C)CCC2)=O)OC)[[email protected]@H](C)CC)C)=O)=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (38.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7647 mL 3.8237 mL 7.6475 mL
5 mM 0.1529 mL 0.7647 mL 1.5295 mL
10 mM 0.0765 mL 0.3824 mL 0.7647 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (0.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (0.96 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (0.96 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Acetylene-linker-Val-Cit-PABC-MMAE1411977-95-1LCB14-0602Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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Acetylene-linker-Val-Cit-PABC-MMAE
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