GS-441524-d
GS-441524-d is the deuterium labeled GS-441524 (HY-103586). GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19).
For research use only. We do not sell to patients.
- CAS No.: 2647440-98-8
- Formula: C12H12DN5O4
- Molecular Weight:292.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT4 | CC50 |
>500 μM
Compound: VV116-N1; X1
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Cytotoxicity against human MT4 cells assessed as reduction in cell viability treated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability treated for 5 days by MTT assay
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[PMID: 37229831] |
| MT4 | CC50 |
500 μM
Compound: VV116-N1; X1
|
Cytotoxicity against human MT4 cells assessed as reduction in cell viability treated for 5 days by MTT assay
Cytotoxicity against human MT4 cells assessed as reduction in cell viability treated for 5 days by MTT assay
|
[PMID: 37229831] |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2647440-98-8
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Unlabeled Cas 1191237-69-0
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Molecular Weight 292.27
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Formula C12H12DN5O4
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SMILES
O[C@@H]1[C@H](O)[C@@H](CO)O[C@@]1(C#N)C2=CC([2H])=C3N2N=CN=C3N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Murphy BG, et al. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233. [Content Brief]
[2]. Huang Z, et al. GS-441524 inhibits African swine fever virus infection in vitro. Antiviral Res. 2021;191:105081. [Content Brief]
[3]. Rasmussen HB, et al. Nucleoside analog GS-441524: pharmacokinetics in different species, safety, and potential effectiveness against Covid-19. Pharmacol Res Perspect. 2022;10(2):e00945. [Content Brief]
[4]. Pedersen NC, et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J Feline Med Surg. 2019;21(4):271-281. [Content Brief]
[5]. Coggins SJ, et al. Outcomes of treatment of cats with feline infectious peritonitis using parenterally administered remdesivir, with or without transition to orally administered GS-441524. J Vet Intern Med. 2023;37(5):1772-1783. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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