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SEC induces activation of ANXA7 GTPase via the AMPK/mTORC1/STAT3 signaling pathway. SEC selectively promotes apoptosis in cancer cells, expressing a high level of ITGB4 by inducing ITGB4 nuclear translocation .
SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM .
SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM .
SEC13 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC62 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC62 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC63 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC63 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC11A Human Pre-designed siRNA Set A contains three designed siRNAs for SEC11A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC16A Human Pre-designed siRNA Set A contains three designed siRNAs for SEC16A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC23A Human Pre-designed siRNA Set A contains three designed siRNAs for SEC23A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC24A Human Pre-designed siRNA Set A contains three designed siRNAs for SEC24A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC31A Human Pre-designed siRNA Set A contains three designed siRNAs for SEC31A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC11C Human Pre-designed siRNA Set A contains three designed siRNAs for SEC11C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC16B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC16B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC22B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC22B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC23B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC23B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC23IP Human Pre-designed siRNA Set A contains three designed siRNAs for SEC23IP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC24B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC24B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC24C Human Pre-designed siRNA Set A contains three designed siRNAs for SEC24C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC24D Human Pre-designed siRNA Set A contains three designed siRNAs for SEC24D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC31B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC31B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC61B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC61G Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC14L1 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC14L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC14L2 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC14L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC14L3 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC14L3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SEC61A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Sel-green, a selective selenol fluorescent probe, is applied to quantify the Sec content in the selenoenzyme thioredoxin reductase and image endogenous Sec in live HepG2 cells .
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities .
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .
Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity .
Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC50 of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer .
Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor .
Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity .
Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .
Sel-green, a selective selenol fluorescent probe, is applied to quantify the Sec content in the selenoenzyme thioredoxin reductase and image endogenous Sec in live HepG2 cells .
Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity .
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .
Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (357a.a, HEK293, Fc) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mucin-1/MUC1 Protein, Human (357a.a, HEK293, Fc) is 357 a.a., with molecular weight of ~70 kDa.
Mucin-1/MUC1 protein and its α subunit have dual functions of adhesion and anti-adhesion proteins, forming a protective layer on epithelial cells. At the same time, the β subunit and its C-terminal domain participate in cell signaling through phosphorylation and protein-protein interactions. Mucin-1/MUC1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Mucin-1/MUC1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Mucin-1/MUC1 Protein, Human (Biotinylated, HEK293, His-Avi) is 269 a.a., with molecular weight of 45-70 kDa.
Enterotoxin type C-2 (SEC2) activates the host immune system by binding the unprocessed molecule to major histocompatibility complex class II and T-cell receptor (TCR) molecules. This interaction forms a ternary complex that activates a large number of T lymphocytes and triggers the widespread release of proinflammatory cytokines. Enterotoxin type C-2 Protein, S. aureus is the recombinant Staphylococcus aureus-derived Enterotoxin type C-2 protein, expressed by E. coli , with tag free. The total length of Enterotoxin type C-2 Protein, S. aureus is 239 a.a., with molecular weight of ~27.6 kDa.
Syntaxin-BP1 Protein crucially regulates synaptic vesicle docking and fusion, binding GTP-binding proteins and ensuring efficient neurotransmission. It interacts with syntaxin in a 1:1 ratio, displaying specificity for syntaxins 1, 2, and 3 (excluding syntaxin 4). Syntaxin-BP1 actively engages in neurotransmitter release by interacting with STX1A, facilitating SNARE complex assembly, recruiting SNAP25 and VAMP2, and mediating neurotransmitter release. It also controls alpha-synuclein/SNCA aggregation and promotes RAB3A dissociation from vesicle membranes, highlighting its multifaceted role in synaptic processes and diverse molecular interactions. Syntaxin-BP1 Protein, Human (sf9, His-GST) is the recombinant human-derived Syntaxin-BP1 protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. The total length of Syntaxin-BP1 Protein, Human (sf9, His-GST) is 594 a.a., with molecular weight of ~80 kDa.