Sec61-IN-5
Sec61-IN-5 (Compound 16c) is a Sec61 inhibitor. Sec61 shows cytotoxicity in A549 cells (IC50: 0.27 nM). Sec61-IN-5 inhibits Sec61-dependent secretory function (IC50: 0.08 nM).
For research use only. We do not sell to patients.
- Formula: C70H113N11O14
- Molecular Weight:1332.71
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
0.27 nM
Compound: 16c
|
Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability incubated for 72 hrs by MTS assay
|
[PMID: 37849553] |
| HCT-116 | CC50 |
0.8 nM
Compound: 16c
|
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
|
[PMID: 37849553] |
| NHDF | CC50 |
0.38 nM
Compound: 16c
|
Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against HDF cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
|
[PMID: 37849553] |
| U-87MG ATCC | CC50 |
0.6 nM
Compound: 16c
|
Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Cytotoxicity against human U87 cells assessed as decrease in cell viability incubated for 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
|
[PMID: 37849553] |
| U-87MG ATCC | IC50 |
0.08 nM
Compound: 16c
|
Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay
Antiproliferative activity against human U-87 MG cells expressing GLuc assessed as as inhibition of GLuc secretion incubated for 18 hrs by CellTiter-Glo Luminescent Cell Viability Assay
|
[PMID: 37849553] |
Chemical Information
-
Molecular Weight 1332.71
-
Formula C70H113N11O14
-
SMILES
CN(C)[C@H](C(O[C@@H](C(N([C@H](C(N(C)[C@@H](CC(C)C)C(N(C)[C@H](C(N(C)[C@H](C(N(C)[C@@H]([C@@H](C)CC)C(N[C@H](C(N(C)[C@H](C(N[C@H](C1=O)CC2=CC=C(C=C2)C3=CC=CC=C3)=O)CC(C)C)=O)C)=O)=O)COC)=O)[C@H](NC([C@@H](C)N1C)=O)C)=O)=O)COC)C)=O)C(C)C)=O)C(C)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz