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Cat. No.: HY-162380

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Topoisomerase II inhibitor 18

Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC₅₀ of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer.

For research use only. We do not sell to patients.

CAS No.: 2382959-65-9
Formula: C₂₀H₂₁N₃OS
Molecular Weight:351.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Topoisomerase II inhibitor 18 Chemical Structure

CAS No.: 2382959-65-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

Topoisomerase II

7.5 μM (IC₅₀)

All Topoisomerase Isoforms :

In Vitro

Topoisomerase II inhibitor 18 (0-100 μM) inhibits proliferations of cancer cells PC-3 and HepG2 with IC₅₀s of 2.11 and 11.03 μM, without significant cytotoxicity in normal cells Vero (IC₅₀ is 23.12 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PC-3
Concentration:

0-100 μM
Incubation Time:

48 h
Result:

Increased levels of p53, cleaved caspase-3 and cleaved caspase-8.
Decreased levels of Bcl-2.

Cell Proliferation Assay^[1]

Cell Line:

HepG2, PC-3
Concentration:

0-100 μM
Incubation Time:

48 h
Result:

Inhibited proliferations of PC-3 and HepG2

In Vivo

Topoisomerase II inhibitor 18 (5 mg/kg, i.m. for 21 days) exhibits antitumor activity in Ehrlich solid tumor bearing albino mice, exhibits kidney protective efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ehrlich solid tumor bearing albino mice^[1]
Dosage:

5 mg/kg
Administration:

i.m. for 21 days
Result:

Inhibited tumor growth.

Chemical Information

CAS No. 2382959-65-9
Molecular Weight 351.47
Formula C₂₀H₂₁N₃OS
SMILES

O=C(NCCC)CCSC1=NC2=CC=CC=C2N=C1C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Elsakka MEG, et al., A quinoxaline-based derivative exhibited potent and selective anticancer activity with apoptosis induction in PC-3 cells through Topo II inhibition. J Biomol Struct Dyn. 2024 Mar 14:1-19. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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