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  3. Aegeline

Aegeline 

Cat. No.: HY-W042156
Handling Instructions

Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity.

For research use only. We do not sell to patients.

Aegeline Chemical Structure

Aegeline Chemical Structure

CAS No. : 456-12-2

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].

In Vitro

Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells[1].
Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin[2].

Molecular Weight

297.35

Formula

C₁₈H₁₉NO₃

CAS No.

456-12-2

SMILES

O=C(NCC(O)C1=CC=C(OC)C=C1)/C=C/C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

AegelineFungalyeastSNAREproteinSec22ptoxicityαsynInhibitorinhibitorinhibit

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