456-12-2
456-12-2
Chemical Structure
Aegeline
- CAS No.: 456-12-2
- Formula:C18H19NO3
- Molecular Weight:297.35
IUPAC Name: N-(2-hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide
InChIKey: QRFDENJATPJOKG-KPKJPENVSA-N
SMILES: O=C(NCC(O)C1=CC=C(OC)C=C1)/C=C/C2=CC=CC=C2
Biological Activity: Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].
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Aegeline | 99.81% | Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity. | ||||||||||||||||||||
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Aegeline (Standard) | ≥98% | Aegeline (Standard) is the analytical standard of Aegeline. This product is intended for research and analytical applications. Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity. | ||||||||||||||||||||
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References
- [1]. Derf A, et al. a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast [published correction appears in Bioorg Med Chem Lett. 2019 Aug 15;29(16):2437-2438]. Bioorg Med Chem Lett. 2019;29(3):454‐460. [Content Brief]
