456-12-2
456-12-2
Chemical Structure
Aegeline
- CAS No.: 456-12-2
- Formula:C18H19NO3
- Molecular Weight:297.35
IUPAC Name: N-(2-hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide
InChIKey: QRFDENJATPJOKG-KPKJPENVSA-N
SMILES: O=C(NCC(O)C1=CC=C(OC)C=C1)/C=C/C2=CC=CC=C2
Biological Activity: Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aegeline | 99.81% | Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity. | ||||||||||||||||||||
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Aegeline (Standard) | ≥98% | Aegeline (Standard) is the analytical standard of Aegeline. This product is intended for research and analytical applications. Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity. | ||||||||||||||||||||
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4'-Methoxychalcone | 99.82% | 4'-Methoxychalcone regulates adipocyte differentiation through PPARγ activation. 4'-Methoxychalcone modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity. | ||||||||||||||||||||
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N-trans-caffeoyloctopamine | N-trans-caffeoyloctopamine is a natural product. | |||||||||||||||||||||
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N-trans-Cinnamoyltyramine | N-trans-Cinnamoyltyramine is a natural product that can be found in osmanthus fragrans. | |||||||||||||||||||||
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Lemairamin | 99.90% | Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of IL-10 and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity. | ||||||||||||||||||||
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N-trans-p-coumaroyloctopamine | 99.21% | N-trans-p-coumaroyloctopamine is a phenylpropanoid amide isolated from eggplant (Solanum melongena L.). | ||||||||||||||||||||
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N-Feruloyloctopamine | 99.91% | N-trans-feruloyloctopamine is a natural hydroxycinnamic acid amide compound derived from garlic outer skin, possessing tyrosinase inhibition, FGF2 inhibition, anti-melanogenic, and anti-tumor activities. N-trans-feruloyloctopamine inhibits tyrosinase activity and downregulates tyrosinase mRNA and protein expression (IC50 = 5.3 μM), and inhibits melanogenesis in α-MSH-stimulated B16F10 cells. N-trans-feruloyloctopamine inhibits Akt and p38 MAPK phosphorylation, binds to E-cadherin to block EMT, reduces Slug, inhibits hepatocellular carcinoma invasion, and induces hepatocellular carcinoma cell apoptosis. N-trans-feruloyloctopamine can be used in research related to hepatocellular carcinoma, pigmentation disorders, and UVB-induced skin damage. | ||||||||||||||||||||
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N-Caffeoyl O-methyltyramine (Standard) | ≥98% | N-Caffeoyl O-methyltyramine (Standard) is the analytical standard of N-Caffeoyl O-methyltyramine. This product is intended for research and analytical applications. N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase (IC50 of 103.58 μM). | ||||||||||||||||||||
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4-Methoxychalcone-1 | 99.20% | 4-Methoxychalcone is a naturally occurring chalcone compound. 4-Methoxychalcone has antioxidant activity, anti-inflammatory activity, antitumor activity and antibacterial activity. 4-Methoxychalcone can be used to study inflammation and tumor models. | ||||||||||||||||||||
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(E)-N-(3-Methoxyphenyl)cinnamamide | (E)-N-(3-Methoxyphenyl) cinnamamide (Compound 5h) is a weakly selective inhibitor of MMP-2 and MMP-9, with weak inhibitory activity against hMMP-2 and hMMP-9, showing IC50 values of 1674.81 nM and 1658.63 nM, respectively, and low selectivity for MMP-1. (E)-N-(3-Methoxyphenyl) cinnamamide is applicable for cancer research. | |||||||||||||||||||||
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(E)-N-(4-Methoxyphenyl)cinnamamide | (E)-N-(4-Methoxyphenyl)cinnamamide is a selective matrix metalloproteinase inhibitor with inhibitory activity against MMP-2 (IC50 = 5.37 nM), MMP-9 (IC50 = 6.21 nM), and low activity against MMP-1 (IC50 = 5301.68 nM). (E)-N-(4-Methoxyphenyl)cinnamamide can be used for the research of tumor. | |||||||||||||||||||||
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References
- [1]. Derf A, et al. a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast [published correction appears in Bioorg Med Chem Lett. 2019 Aug 15;29(16):2437-2438]. Bioorg Med Chem Lett. 2019;29(3):454‐460. [Content Brief]
