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Bragsin1 

Cat. No.: HY-111549 Purity: 99.68%
Handling Instructions

Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity.

For research use only. We do not sell to patients.

Bragsin1 Chemical Structure

Bragsin1 Chemical Structure

CAS No. : 369631-68-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity[1].

IC50 & Target

IC50: 3 μM (BRAG2)[1]

Molecular Weight

273.16

Formula

C₁₁H₆F₃NO₄

CAS No.

369631-68-5

SMILES

O=C1C=C(C(F)(F)F)OC2=CC=C(C)C([N+]([O-])=O)=C21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (228.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6609 mL 18.3043 mL 36.6086 mL
5 mM 0.7322 mL 3.6609 mL 7.3217 mL
10 mM 0.3661 mL 1.8304 mL 3.6609 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Bragsin1Bragsin 1Bragsin-1OthersInhibitorinhibitorinhibit

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Product Name:
Bragsin1
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HY-111549
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