Syntaxin Binding Protein 1 Antibody (YA2620)
(Synonyms: STXBP1; UNC18A; Syntaxin-binding protein 1; MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67)
Based on 1 Customer Validation
Syntaxin Binding Protein 1 Antibody (YA2620) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Syntaxin Binding Protein 1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:200 | 1:50-1:200 |
Product Details
Syntaxin Binding Protein 1 Antibody (YA2620) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Syntaxin Binding Protein 1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 65 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 68 kDa
Entrez Gene: 6812 Human ; 20910 Mouse ; 25558 Rat
SwissProt: P61764 Human ; O08599 Mouse ; P61765 Rat
OMIM: 612164 Human
A synthesized peptide derived from human STXBP1 aa440-492.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Syntaxin Binding Protein 1 participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes. May play a role in determining the specificity of intracellular fusion reactions
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Subcellular Localization
Cytoplasm, cytosol; Membrane; Peripheral membrane protein
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Expression
Tissue_specificity:Brain and spinal cord. Highly enriched in axons -
Isoforms & Post-Translational Modification
P61764 has 2 isomers: P61764-1: 67569 Da (predicted); P61764-2: 68736 Da (predicted).
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Subunit
Interacts with SYTL4 (By similarity). Interacts with STX1A (PubMed:12730201). The interaction recruits SNARE complex components SNAP25 and VAMP2 and mediates neurotransmitter release from neurons (By similarity). Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation (PubMed:27597756). Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with CABP5 (By similarity)
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SwissProt ID
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Synonyms
STXBP1; UNC18A; Syntaxin-binding protein 1; MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67
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Research Field
Neuroscience
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