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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Syntaxin Binding Protein 1 Antibody (YA2620)

Syntaxin Binding Protein 1 Antibody (YA2620)

Cat. No.: HY-P82875
COA
SDS
User Guide for Antibodies Technical Support

Syntaxin Binding Protein 1 Antibody (YA2620) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Syntaxin Binding Protein 1.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

  • References

Description

Syntaxin Binding Protein 1 Antibody (YA2620) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Syntaxin Binding Protein 1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 68 kDa;
Observed band size: 65 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human STXBP1 aa440-492.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:2000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions
Subcellular Localization：Cytoplasm, cytosol; Membrane; Peripheral membrane protein
Expression：
Tissue_specificity:Brain and spinal cord. Highly enriched in axons
Isoforms & Post-Translational Modification：P61764 has 2 isomers: P61764-1: 67569 Da (predicted); P61764-2: 68736 Da (predicted).
Subunit：Interacts with SYTL4 (By similarity). Interacts with STX1A (PubMed:12730201). The interaction recruits SNARE complex components SNAP25 and VAMP2 and mediates neurotransmitter release from neurons (By similarity). Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation (PubMed:27597756). Interacts with RAB3A; this interaction promotes RAB3A dissociation from the vesicle membrane (By similarity). Interacts with CABP5 (By similarity)
Database

Entrez Gene: 6812 Human ; 20910 Mouse ; 25558 Rat

SwissProt: P61764 Human ; O08599 Mouse ; P61765 Rat

OMIM: 612164 Human

Research Field

Neuroscience
Synonyms
STXBP1; UNC18A; Syntaxin-binding protein 1; MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67
Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)
References

Syntaxin Binding Protein 1 Antibody (YA2620) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Syntaxin Binding Protein 1 Antibody (YA2620)
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