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Results for "

TCS

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

3

Peptides

1

Recombinant Proteins

4

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100452
    TCS-OX2-29
    3 Publications Verification

    		 Orexin Receptor (OX Receptor) Endocrinology Cancer
    TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1 .
    TCS-OX2-29
  • HY-107598
    JNK Inhibitor VIII
    3 Publications Verification

    TCS JNK 6o

    		 JNK Cancer
    JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively .
    JNK Inhibitor VIII
  • HY-16576A
    SMI-4a
    1 Publications Verification

    TCS-PIM-1-4a

    		 Pim Cancer
    SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 μM. SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity .
    SMI-4a
  • HY-10319
    BAY-549
    4 Publications Verification

    ROCK-IN-2; Azaindole 1; TC-S 7001

    		 ROCK Cardiovascular Disease
    BAY-549 (Azaindole 1), a chemical probe, is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2, respectively .
    BAY-549
  • HY-70061
    TCS7010
    2 Publications Verification

    		 Aurora Kinase Apoptosis Cancer
    TCS7010 is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.
    TCS7010
  • HY-15881
    TCS JNK 5a
    2 Publications Verification

    JNK Inhibitor IX

    		 JNK Apoptosis Cancer
    TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.
    TCS JNK 5a
  • HY-18371
    TC-S 7009
    1 Publications Verification

    		 HIF/HIF Prolyl-Hydroxylase Inflammation/Immunology
    TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd ? 5 μM). TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression .
    TC-S 7009
  • HY-15065
    Chembridge-5861528
    1 Publications Verification

    TCS 5861528

    		 TRP Channel Neurological Disease Metabolic Disease Inflammation/Immunology
    Chembridge-5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. Chembridge-5861528 shows antihypersensitivity activities .
    Chembridge-5861528
  • HY-108597
    TC-S 7005
    4 Publications Verification

    		 Polo-like Kinase (PLK) Cardiovascular Disease Inflammation/Immunology
    TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively .
    TC-S 7005
  • HY-18086
    TCS PIM-1 1
    4 Publications Verification

    SC 204330

    		 Pim Cancer
    TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM) .
    TCS PIM-1 1
  • HY-10900
    TCS 1102
    1 Publications Verification

    		 Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively. TCS 1102 demonstrates excellent blood-brain barrier penetrability and moderate bioavailability in rats .
    TCS 1102
  • HY-12312
    TCS 401
    2 Publications Verification

    		 Phosphatase Metabolic Disease
    TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
    TCS 401
  • HY-108264
    TCS 21311

    NIBR3049

    		 JAK PKC GSK-3 Cancer
    TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively .
    TCS 21311
  • HY-108557
    TCS 2510

    CAY10598

    		 Prostaglandin Receptor Metabolic Disease
    TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases .
    TCS 2510
  • HY-13907
    TCS 359
    1 Publications Verification

    		 FLT3 Cancer
    TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent and selective FLT3 inhibitor with an IC50 of 42 nM. TCS 359 inhibits MV4-11 cell proliferation with an IC50 of 340 nM .
    TCS 359
  • HY-12308
    TCS 2314

    		Integrin Inflammation/Immunology
    TCS 2314 (compound 3) is orally active and selective very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM .
    TCS 2314
  • HY-10096
    TCS2002

    		GSK-3 Neurological Disease
    TCS2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM. TCS2002 shows good pharmacokinetic profiles including favorable BBB penetration. TCS2002 can be used for the research of Alzheimer’s disease .
    TCS2002
  • HY-103511
    TCS1105

    		GABA Receptor Neurological Disease
    TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion .
    TCS1105
  • HY-107707
    TCS 46b

    		iGluR Neurological Disease
    TCS 46b (Compound 46b) is a potent, selective and orally active NMDA NR1A/2B receptor antagonist with an IC50 of 5.3 nM . TCS 46b is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    TCS 46b
  • HY-108438
    TCS 2210

    		Microtubule/Tubulin Neurological Disease
    TCS 2210 (compound 1) is a neuronal differentiation inducer in mesenchymal stem cells (MSCs). TCS 2210 increases expression of the neuronal markers β-III tubulin and neuron-specific enolase (NSE) .
    TCS 2210
  • HY-100452A
    TCS-OX2-29 hydrochloride

    OX2R antagonist

    		 Orexin Receptor (OX Receptor) Endocrinology Cancer
    TCS-OX2-29 (hydrochloride) is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1 .
    TCS-OX2-29 hydrochloride
  • HY-P1385
    TCS 183

    		GSK-3 p38 MAPK Neurological Disease
    TCS 183, a peptide, is a GSK-3β inhibitor. TCS 183 blocks GSK-3β autoinhibition and decreases the level of AMPK phosphorylation. TCS 183 can be used for neuropathological diseases, particularly Alzheimer’s disease, research .
    TCS 183
  • HY-12312A
    TCS 401 free base

    		Phosphatase Metabolic Disease
    TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
    TCS 401 free base
  • HY-107662
    TCS PrP Inhibitor 13

    		Apoptosis Infection Cancer
    TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrP C) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .
    TCS PrP Inhibitor 13
  • HY-RS14320
    TCOF1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TCOF1 Human Pre-designed siRNA Set A contains three designed siRNAs for TCOF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TCOF1 Human Pre-designed siRNA Set A
    TCOF1 Human Pre-designed siRNA Set A
  • HY-10900R
    TCS 1102 (Standard)

    		Reference Standards Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    TCS 1102 (Standard) is the analytical standard of TCS 1102 (HY-10900). This product is intended for research and analytical applications. TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively. TCS 1102 demonstrates excellent blood-brain barrier penetrability and moderate bioavailability in rats .
    TCS 1102 (Standard)
  • HY-108264R
    TCS 21311 (Standard)

    NIBR3049 (Standard)

    		 Reference Standards JAK PKC GSK-3 Cancer
    TCS 21311 (Standard) is the analytical standard of TCS 21311 (HY-108264). This product is intended for research and analytical applications. TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively .
    TCS 21311 (Standard)
  • HY-107662R
    TCS PrP Inhibitor 13 (Standard)

    		Reference Standards Apoptosis Infection Cancer
    TCS PrP Inhibitor 13 (Standard) is the analytical standard of TCS PrP Inhibitor 13 (HY-107662). This product is intended for research and analytical applications. TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis .
    TCS PrP Inhibitor 13 (Standard)
  • HY-100452R
    TCS-OX2-29 (Standard)

    		Orexin Receptor (OX Receptor) Reference Standards Endocrinology Cancer
    TCS-OX2-29 (Standard) is the analytical standard of TCS-OX2-29 (HY-100452). This product is intended for research and analytical applications. TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1 .
    TCS-OX2-29 (Standard)
  • HY-107598R
    JNK Inhibitor VIII (Standard)

    TCS JNK 6o (Standard)

    		 Reference Standards JNK Cancer
    JNK Inhibitor VIII (Standard) is the analytical standard of JNK Inhibitor VIII (HY-107598). This product is intended for research and analytical applications. JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal Kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively .
    JNK Inhibitor VIII (Standard)
  • HY-10319R
    BAY-549 (Standard)

    ROCK-IN-2 (Standard); Azaindole 1 (Standard); TC-S 7001 (Standard)

    		 Reference Standards ROCK Cardiovascular Disease
    BAY-549 (Standard) is the analytical standard of BAY-549 (HY-10319). This product is intended for research and analytical applications. BAY-549 (Azaindole 1), a chemical probe, is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2, respectively .
    BAY-549 (Standard)

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