1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. Aurora Kinase
    Apoptosis
  3. TCS7010

TCS7010 

Cat. No.: HY-70061 Purity: 98.74%
Handling Instructions

TCS7010 is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.

For research use only. We do not sell to patients.

TCS7010 Chemical Structure

TCS7010 Chemical Structure

CAS No. : 1158838-45-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 109 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 468 In-stock
Estimated Time of Arrival: December 31
100 mg USD 864 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

TCS7010 is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.

IC50 & Target[1]

Aurora A

3.4 nM (IC50)

Aurora B

3.4 μM (IC50)

In Vitro

TCS7010 is exceptionally selective Aurora A inhibitors. TCS7010 is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

588.08

Formula

C₃₁H₃₁ClFN₇O₂

CAS No.

1158838-45-9

SMILES

O=C(C1=CC=C(C=C1)NC2=C(F)C=NC(NC3=CC=C(C=C3)CC(N4CCN(CC4)CC)=O)=N2)NC5=CC=CC=C5Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (170.04 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7004 mL 8.5022 mL 17.0045 mL
5 mM 0.3401 mL 1.7004 mL 3.4009 mL
10 mM 0.1700 mL 0.8502 mL 1.7004 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

TCS7010TCS 7010TCS-7010Aurora KinaseApoptosisInhibitorinhibitorinhibit

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TCS7010
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