TCS 401 free base
Based on 2 publication(s) in Google Scholar
TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
For research use only. We do not sell to patients.
- CAS No.: 243967-42-2
- Formula: C10H10N2O5S
- Molecular Weight:270.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) TCS 401 free base
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Biological Activity
Chemical Information
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CAS No. 243967-42-2
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Molecular Weight 270.26
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Formula C10H10N2O5S
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SMILES
O=C(C(NC1=C(C(O)=O)C(CCNC2)=C2S1)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Tissue Eng Regen Med
Inhibition of protein-tyrosine phosphatase 1B phosphorylation enhances early adhesion of mesenchymal stem cells to facilitate fabrication of tissue-engineered bone. [Abstract]2020 Apr;14(4):575-587. PMID: 32061178
TCS 401 free base purchased from MedChemExpress. Usage Cited in: J Tissue Eng Regen Med. 2020 Apr;14(4):575-587. [Abstract]
The activation of Src by treatment with the 152RM peptide is reversed by pretreatment with the PTP1B inhibitor TCS-401, and the increased phosphorylation of β-catenin Y654 by treatment with the 152RM peptide is reduced by pretreatment with the Src inhibitor bosutinib.
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In Vitro Cell Dev Biol Anim
Angiotensin II induces apoptosis of cardiac microvascular endothelial cells via regulating PTP1B/PI3K/Akt pathway. [Abstract]2019 Dec;55(10):801-811. PMID: 31502193
Purity & Documentation
References
[1]. Du ZD, et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis. 2015 May 1;21:523-31. [Content Brief]
[2]. Ponnusamy M, et al. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F698-709. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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